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Mathur, S., Mincher, D., Turnbull, A., Stevens, C. & Poole, A. (2016). Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer. 61, S142. doi:10.1016/s0959-8049(16)61501-0. ISSN 0959-8049
Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biom...
Turnbull, A. Design and development of novel DNA Topoisomerase inhibitors. (Thesis)
OLUWADARE, E., REHAN, A., DING, Y., Turnbull, A., Malone, E., MINCHER, D., & PROUDFOOT, L. (2016, September). Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece
Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Red...
Dias, N., Goossens, J., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., …Bailly, C. (2005). Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry. 16, 949 - 958. doi:10.1021/bc050065x. ISSN 1043-1802
We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derive...
Mincher, D. & Turnbull, A. (2004). Anthracene derivatives as anti-cancer agents.
The present invention relates to compounds which are based on an anthraquinone nucleus for use in medicine, particularly as anti-cancer agents which exert their effects throug...
The majority of clinically used anticancer drugs suffer from poor selectivity for tumour cells ...