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Design, synthesis and evaluation of novel endoprotease-activated prodrugs and fluorogenic probes with theranostic applications in chemotherapy

Thesis
Ding, Y. Design, synthesis and evaluation of novel endoprotease-activated prodrugs and fluorogenic probes with theranostic applications in chemotherapy. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/7555
Proteolytic degradation of the extracellular matrix (ECM) by overexpressed endoproteases, notably the matrix metalloproteinase MMP-9 and legumain (human asparaginyl endopeptid...

Design and synthesis of novel prodrugs to modulate GABA receptors in cancer

Thesis
Zhang, H. Design and synthesis of novel prodrugs to modulate GABA receptors in cancer. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/978678
GABA (gamma-amino butanoic acid) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA has been found to play an inhibitory role in some cancer...

Design and evaluation of novel fluorogenic probes and prodrugs in cancer.

Thesis
Mather, S. Design and evaluation of novel fluorogenic probes and prodrugs in cancer. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1034936
Despite major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection (poor selectivity and specificity). Legumain [aspara...

Biochemistry of topoisomerase inhibtion and cellular mechanisms of anthraquinone-amino acid conjugates in vitro.

Thesis
Pettersson, S. Biochemistry of topoisomerase inhibtion and cellular mechanisms of anthraquinone-amino acid conjugates in vitro. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/4160

Design and development of novel DNA Topoisomerase inhibitors.

Thesis
Turnbull, A. Design and development of novel DNA Topoisomerase inhibitors. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/3870