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Design and synthesis of novel prodrugs to modulate GABA receptors in cancer

Thesis
Zhang, H. Design and synthesis of novel prodrugs to modulate GABA receptors in cancer. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/978678
GABA (gamma-amino butanoic acid) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA has been found to play an inhibitory role in some cancer...

P4-12-01: The Breast-Activity and Healthy Eating after Diagnosis (B-AHEAD) Study – A Randomised Comparison of Weight Control Programmes during Adjuvant Treatment.

Journal Article
Campbell, A., Harvie, M., Pegington, M., Bundred, N., Campbell, A., Wolstenholme, J., …Howell, A. (2011)
P4-12-01: The Breast-Activity and Healthy Eating after Diagnosis (B-AHEAD) Study – A Randomised Comparison of Weight Control Programmes during Adjuvant Treatment. Cancer Research, 71(24 Supplement), P4-12-01-P4-12-01. https://doi.org/10.1158/0008-5472.sabcs11-p4-12-01
Abstracts: Thirty-Fourth Annual CTRC-AACR San Antonio Breast Cancer Symposium-- Dec 6-10, 2011; San Antonio, TXBackground: Excess weight at diagnosis and weight gain during tr...

The Cancer Rehabilitation Journey: Barriers to and Facilitators of Exercise Among Patients With Cancer-Related Fatigue

Journal Article
Blaney, J., Lowe-Strong, A., Rankin, J., Campbell, A., Allen, J., & Gracey, J. (2010)
The Cancer Rehabilitation Journey: Barriers to and Facilitators of Exercise Among Patients With Cancer-Related Fatigue. Physical Therapy, 90(8), 1135-1147. https://doi.org/10.2522/ptj.20090278
Background Despite the evidence to support exercise as an effective management strategy for patients with cancer-related fatigue (CRF), many of the general cancer population a...

Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model.

Journal Article
Van Valckenborgh, E., Mincher, D., Di Salvo, A., Van Riet, I., Young, L., Van Camp, B., & Vanderkerken, K. (2005)
Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia, 19, 1628-1633. https://doi.org/10.1038/sj.leu.2403866
Multiple myeloma (MM) is an incurable B-cell cancer characterised by the monoclonal proliferation of tumour cells in the bone marrow (BM). It has been described that matrix me...

Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial

Journal Article
Pegington, M., Adams, J. E., Bundred, N. J., Harvie, M. N., Campbell, A., Howell, A., …Harvey, M. (2018)
Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial. Integrative Cancer Therapies, 17(1), 131-137. https://doi.org/10.1177/1534735416687850
Excess weight at breast cancer diagnosis and weight gain during treatment are linked to increased breast cancer specific and all-cause mortality. The Breast—Activity and Healt...

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle

Journal Article
Qiu, G., Salto-Tellez, M., Ross, J. A., Yeo, W., Cui, Y., Wheelhouse, N., …Hooi, S. C. (2008)
The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. Journal of Hepatology, 48(3), 433-441. https://doi.org/10.1016/j.jhep.2007.11.015
Background/Aims: The chromosome locus 3p21.3 is a ‘‘hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of t...

Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship

Journal Article
Christensen, J. F., Bandak, M., Campbell, A., Jones, L. W., & Højman, P. (2015)
Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship. Acta oncologica, 54(5), 592-599. https://doi.org/10.3109/0284186x.2014.995776
Treatment of testicular germ cell cancer constitutes a major success story in modern oncology. Today, the vast majority of patients are cured by a therapeutic strategy using o...

Physical Activity Levels of Women Attending Glasgow Breast Clinics

Journal Article
Tan, A., Pavlidou, E., Ogston, K., Doughty, J., Wilson, C., Campbell, A., & Tovey, S. (2009)
Physical Activity Levels of Women Attending Glasgow Breast Clinics. Cancer Research, 69(24 Supplement), 2066-2066. https://doi.org/10.1158/0008-5472.sabcs-09-2066
Introduction Epidemiological studies suggest that moderate intensity recreational physical activity (PA) improves breast cancer survival. We aimed to assess the current levels...

Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks

Journal Article
Lowrie, A. G., Dickinson, P., Wheelhouse, N., Stewart, G. D., Ross, A. J., Forster, T., & Ross, J. A. (2011)
Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks. International Journal of Oncology, 39(3), 709-18. https://doi.org/10.3892/ijo.2011.1064
Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic c...

Design and evaluation of novel fluorogenic probes and prodrugs in cancer.

Thesis
Mather, S. Design and evaluation of novel fluorogenic probes and prodrugs in cancer. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1034936
Despite major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection (poor selectivity and specificity). Legumain [aspara...