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Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles

Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., …Stone, V. (2004)
Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003
Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have ...

Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response

Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2014)
Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), https://doi.org/10.1371/journal.pone.0102386
BACKGROUND Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep

Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., …Buxton, D. (2013)
Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0057950
BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a ...

Identification and characterisation of an Old Yellow Enzyme (OYE) - NamA from Listeria monocytogenes

Thesis
Bamaga, M. A. Identification and characterisation of an Old Yellow Enzyme (OYE) - NamA from Listeria monocytogenes. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/9831
The food-borne pathogene Listeria monocytogenes has been considered a significant threat to human health worldwide. It mainly infects individuals suffering insuffecint immunit...

Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

Journal Article
Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2013)
Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), https://doi.org/10.4161/onci.22590
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lympho...

Antiviral potential of cathelicidins

Journal Article
Barlow, P. G., Findlay, E. G., Currie, S. M., & Davidson, D. J. (2014)
Antiviral potential of cathelicidins. Future Microbiology, 9(1), 55-73. https://doi.org/10.2217/fmb.13.135
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of i...

A role for immunology in 'next generation' robots.

Conference Proceeding
Hart, E., Ross, P., Webb, A., & Lawson, A. (2003)
A role for immunology in 'next generation' robots. In J. Timmis, P. Bentley, & E. Hart (Eds.), Artificial Immune Systems. ICARIS 2003, 46-56. https://doi.org/10.1007/978-3-540-45192-1_5
Much of current robot research is about learning tasks in which the task to be achieved is pre-specified, a suitable technology for the task is chosen and the learning process...

Parasitic helminths tip the balance: potential anti-inflammatory therapies

Journal Article
Proudfoot, L. (2004)
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x
Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a...

Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation

Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008)
Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x
The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha produc...

Antibiotic prescribing: the consequences of getting it wrong

Journal Article
Dancer, S. J. (2016)
Antibiotic prescribing: the consequences of getting it wrong. Clinical Focus Primary Care, 10(2), 62-71
Antibiotics were one of the most important discoveries last century. As with all drugs, however, they are associated with adverse effects. This article reviews how inappropria...

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