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Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

Journal Article
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012)
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLOS ONE, 7(7), e40569. https://doi.org/10.1371/journal.pone.0040569
Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the d...

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

Journal Article
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism, 11(1), 35-46. https://doi.org/10.1016/j.cmet.2009.11.010
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms includi...

Phosphorylation of the epidermal growth factor receptor (EGFR) is essential for interleukin-8 release from intestinal epithelial cells in response to challenge with Escherichia coli O157 :H7 flagellin.

Journal Article
Fraser-Pitt, D. J., Cameron, P., McNeilly, T. N., Boyd, A., Manson, E. D. T., & Smith, D. G. E. (2011)
challenge with Escherichia coli O157 :H7 flagellin. Microbiology, 157, 2339-2347. https://doi.org/10.1099/mic.0.047670-0
Enterohaemorrhagic E. coli O157:H7 is a major food-borne and environmental pathogen responsible for both sporadic cases and outbreaks of food poisoning which can lead to serio...

Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro.

Thesis
Clift, M. J. D. Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2557
Quantum dots (QDs) are potentially advantageous tools for both diagnostics and therapeutics due to their light emitting characteristics. The impact of QDs on biological system...

DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.

Journal Article
Harrison, B., Kraus, M., Burch, L., Stevens, C., Craig, A., Gordon-Weeks, P., & Hupp, T. R. (2008)
DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. Journal of Biological Chemistry, 283(15), 9999-10014. https://doi.org/10.1074/jbc.M706040200
DAPK-1 (death-activated protein kinase) has wide ranging functions in cell growth control; however, DAPK-1 interacting proteins that mediate these effects are not well defined...

A Central Role for CK1 in Catalyzing Phosphorylation of the p53 Transactivation Domain at Serine 20 after HHV-6B Viral Infection.

Journal Article
MacLaine, N. J., Øster, B., Bundgaard, B., Fraser, J. A., Buckner, C., Lazo, P. A., …Hupp, T. R. (2008)
A Central Role for CK1 in Catalyzing Phosphorylation of the p53 Transactivation Domain at Serine 20 after HHV-6B Viral Infection. Journal of Biological Chemistry, 283, 28563-28573. https://doi.org/10.1074/jbc.M804433200
The tumor suppressor protein p53 is activated by distinct cellular stresses including radiation, hypoxia, type I interferon, and DNA/RNA virus infection. The transactivation d...

A comparison of five rapid direct toxicity assessment methods to determine toxicity of pollutants to activated sludge

Journal Article
de la Sota, A., Aspichueta, E., Dalzell, D., Dalzell, D., Alte, S., Aspichueta, E., …Christofi, N. (2002)
A comparison of five rapid direct toxicity assessment methods to determine toxicity of pollutants to activated sludge. Chemosphere, 47(5), 535-545. doi:10.1016/s0045-6535(01)00331-9
Five rapid direct toxicity assessment methods were used in three European partner countries to determine the toxicity of single toxicants, mixed toxicants and real industrial ...

Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway.

Journal Article
Hupp, T., Lin, Y., Henderson, P., Pettersson, S., Satsangi, J., Hupp, T. R., & Stevens, C. (2010)
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS Journal, 278(2), 354-370. https://doi.org/10.1111/j.1742-4658.2010.07959.x
We previously identified a novel interaction between tuberous sclerosis-2 (TSC2) and death-associated protein kinase-1 (DAPK), the consequence being that DAPK catalyses the in...

Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling.

Journal Article
Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. J., & Hupp, T. R. (2009)
Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284, 334-344. https://doi.org/10.1074/jbc.M805165200
Death-associated protein kinase (DAPK) is a multidomain enzyme that plays a central role in autophagic and apoptotic signaling, although the protein-protein interactions regul...

Free-CoA mediated regulation of intermediary and central metabolism: An hypothesis, which accounts for the excretion of α-ketoglutarate during aerobic growth of E. coli on acetate

Journal Article
El-Mansi, M. (2005)
Free-CoA mediated regulation of intermediary and central metabolism: An hypothesis, which accounts for the excretion of α-ketoglutarate during aerobic growth of E. coli on acetate. Research in Microbiology, 156(8), (874-879). doi:10.1016/j.resmic.2005.04.008. ISSN 0923-2508
During growth of Escherichia coli on acetate, phosphotransacetylase and -ketoglutarate dehydrogenase are in direct competition for their common co-factor, HS-CoA. Such competi...