Research explorer tool

10 results

The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4

Journal Article
Brown, D. M., HUTCHISON, L., DONALDSON, K., MACKENZIE, S., DICK, C., & STONE, V. (2007)
The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4. Toxicology Letters, 168(1), 1-6. doi:10.1016/j.toxlet.2006.10.016
Reactive oxygen species (ROS) have been implicated in various pulmonary diseases by causing direct injury to lung epithelial cells. Signalling activity of cells through transc...

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...

Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ

Journal Article
Kermanizadeh, A., Brown, D. M., Hutchison, G. R., & Stone, V. (2012)
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ. Journal of Nanomedicine and Nanotechnology, 4, 157. https://doi.org/10.4172/2157-7439.1000157
Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), some Nanomaterials (NMs) translocate to secondary tissues, prominently ...

An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis.

Journal Article
Brown, D. M., Kinloch, I. A., Bangert, U., Windle, A., Walter, D. M., Walker, G. S., …Stone, V. (2007)
An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. Carbon, 45, 1743-1756. https://doi.org/10.1016/j.carbon.2007.05.011
There has been little information to date based on the potential health effects and hazards associated with the inhalation of carbon nanofibrous materials by workers despite t...

Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles

Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., …Stone, V. (2004)
Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003
Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have ...

The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation.

Journal Article
Hutchison, G. R., Brown, D. M., Hibbs, L. R., Heal, M. R., Donaldson, K., Maynard, R. L., …Stone, V. (2005)
The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation. Respiratory Research. 6, 43. doi:10.1186/1465-9921-6-43. ISSN 1465-9921
In the year 2000 Corus closed its steel plant operations in Redcar, NE of England temporarily for refurbishment of its blast furnace. This study investigates the impact of the...

The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists.

Journal Article
Brown, D. M., Hutchison, L., Donaldson, K. & Stone, V. (2007)
The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. American journal of physiology. Lung cellular and molecular physiology. 292, L1444-L1451. doi:10.1152/ajplung.00162.2006. ISSN 1522-1504
We have previously examined the ability of air pollution particles (PM10) to promote release of the proinflammatory cytokine tumor necrosis factor- (TNF-) from human periphera...

Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium.

Journal Article
Moller, W., Brown, D. M., Kreyling, L. & Stone, V. (2005)
Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium. Particle and Fibre Toxicology. 2, 7. doi:10.1186/1743-8977-2-7. ISSN 1743-8977
Background Particulate air pollution is reported to cause adverse health effects in susceptible individuals. Since most of these particles are derived form combustion processe...

Effects of PM10 in human peripheral blood monocytes and J774 macrophages.

Journal Article
Brown, D. M., Donaldson, K. & Stone, V. (2004)
Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respiratory research. 5, 29. doi:10.1186/1465-9921-5-29. ISSN 1465-9921
The effects of PM10, one of the components of particulate air pollution, was investigated using human monocytes and a mouse macrophage cell line (J774). The study aimed to inv...

Proinflammatory effects of particles on macrophages and epithelial cells.

Book
Brown, D., Hutchison, G., Stone, V. & Barlow, P. (2006)
Proinflammatory effects of particles on macrophages and epithelial cells. In Particle Toxicology, 183-196. Informa UK Limited. doi:10.1201/9781420003147.ch9. ISBN 978-0-8493-5092-4; 978-1-4200-0314-7