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Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential

Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5(February 2020), https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (in press)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment

Journal Article
Boukelia, Z., Gomes, E. C., & Florida-James, G. D. (2018)
Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment. Oxidative Medicine and Cellular Longevity, 2018, https://doi.org/10.1155/2018/3402143
Purpose. The purpose of this study was to investigate the physiological and immunological response of highly trained runners to an intense bout of exercise performed at two di...

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...

Antiviral therapeutic approaches for human rhinovirus infections

Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018)
Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016
Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated wit...

Researching effective approaches to cleaning in hospitals: protocol of the REACH study, a multi-site stepped-wedge randomised trial

Journal Article
Hall, L., Farrington, A., Mitchell, B. G., Barnett, A. G., Halton, K., Allen, M., …Graves, N. (2016)
Researching effective approaches to cleaning in hospitals: protocol of the REACH study, a multi-site stepped-wedge randomised trial. Implementation Science, 11(1), https://doi.org/10.1186/s13012-016-0406-6
Background The Researching Effective Approaches to Cleaning in Hospitals (REACH) study will generate evidence about the effectiveness and cost-effectiveness of a novel cleanin...

Is there an association between airborne and surface microbes in the critical care environment?

Journal Article
Smith, J., Adams, C., King, M., Noakes, C., Robertson, C., & Dancer, S. (2018)
Is there an association between airborne and surface microbes in the critical care environment?. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2018.04.003
Background There are few data and no accepted standards for air quality in the intensive care unit (ICU). Any relationship between airborne pathogens and hospital-acquired inf...

Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’

Journal Article
Dancer, S. (2016)
Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’. Journal of Hospital Infection, 92(2), 208-209. https://doi.org/10.1016/j.jhin.2015.10.020
Letter to Editor. Refers to - J.-Y. Maillard, S.A. Sattar, C. Bradley Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from su...

Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity

Journal Article
Ross, M. D. (2018)
Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity. Current Cardiology Reviews, 14(4), 233-244. doi:10.2174/1573403X14666180726112303
The endothelium plays an important role in cardiovascular regulation, from blood flow, to platelet aggregation, immune cell infiltration and demargination. A dysfunctional end...

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction

Journal Article
Lin, Y., Hupp, T. R., & Stevens, C. (2009)
Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), (48-57). ISSN 1742-464X
Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the...
26 results

Polycystic ovary syndrome (PCOS) developmental model

2010 - 2014
Polycystic ovary syndrome (PCOS) is common: more than one in 1 in 15 young women has this condition. There are many associated health problems including abnormal periods, miscarriages, infertility, ex...
Funder: Medical Research Council | Value: £130,956

PhD studentship for CIRCA

2014 - 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the ...
Funder: Crohn's in Childhood Research Association | Value: £68,577

Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention

2017 - 2021
Risks of developing many adult illnesses are set down as we develop in the womb, hence the environment we experience during fetal life needs to be ‘just right’. Understanding how the fetal environmen...
Funder: Medical Research Council | Value: £636,509

Biochemical Society Summer Vacation Scholarship

2017 - 2017
Nrf2, a transcriptional activator of cell protection genes, is an emerging target for neurodegenerative conditions including Alzheimer’s disease (AD). Nrf2 activity is reduced in dementia patients and...
Funder: Biochemical Society | Value: £1,600

Acceptability of extragenital Chlamydia testing

2017 - 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
Funder: Chief Scientists Office | Value: £27,998

IDEA

2017 - 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Funder: Crohn's in Childhood Research Association | Value: £5,274

Development of a UV-C hand-sanitiser unit

2017 - 2017
Development of a UV-C hand-sanitiser unit
Funder: Scottish Funding Council | Value: £5,000

TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.

2018 - 2019
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.
Funder: British Council | Value: £75,000

Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China

2018 - 2020
Investigating new therapies for osteoarthritis: a collaboration between ENU and Guangzhou Medical University, China Osteoarthritis is the most important ageing-related disease, estimated to affect 13...
Funder: ENU Development Trust | Value: £30,000

Does the gut microbiome play a role in polycystic ovary syndrome?

2017 - 2018
Does the gut microbiome play a role in polycystic ovary syndrome?
Funder: Society for Reproduction and Fertility | Value: £12,250