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Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats.

Journal Article
Montori, S., Dos Anjos, S., Poole, A. V., Regueiro-Purrinos, M. M., Llorente, I. L., Darlison, M. G., …Martínez-Villayandre, B. (2012)
Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats. Neuropathology and Applied Neurobiology, 38, 710-722. https://doi.org/10.1111/j.1365-2990.2012.01254.x
Aims: This study has investigated how global brain ischaemia/reperfusion (I/R) modifies levels of mRNAs encoding GABA(A) receptor alpha1, beta2 and gamma2 subunits and glutami...

Diurnal variation in physiological, psychological and immune responses to running 10 km time trials performed in hot and cold environments

Thesis
Boukelia, B. Diurnal variation in physiological, psychological and immune responses to running 10 km time trials performed in hot and cold environments. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/9162
Purpose: To investigate the physiological, immunological and psychological response to an intense bout of exercise performed by highly trained individuals at 09:00 hs and 16:0...

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart

Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., …Denvir, M. A. (2015)
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025
Background Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations o...

Drosophila cohesins DSA1 and Drad21 persist and colocalize along the centromeric heterochromatin during mitosis

Journal Article
Valdeolmillos, A., Rufas, J. S., Suja, J. A., Vass, S., Heck, M. M., Martínez-A, C., & Barbero, J. L. (2004)
Drosophila cohesins DSA1 and Drad21 persist and colocalize along the centromeric heterochromatin during mitosis. Biology of the Cell, 96(6), 457-462. doi:10.1016/j.biolcel.2004.04.011
Sister chromatid cohesion in eukaryotes is maintained mainly by a conserved multiprotein complex termed cohesin. Drad21 and DSA1 are the Drosophila homologues of the yeast Scc...

Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling

Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012)
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031
Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalli...

Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis

Journal Article
Keir, P. A., Brown, D. M., Clouter-Baker, A., Harcus, Y. M., & Proudfoot, L. (2004)
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26(3), 137-139. https://doi.org/10.1111/j.0141-9838.2004.00692.x
It has been reported that excretory–secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune syst...

Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity

Thesis
Cosgrove, C. Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity. (Thesis)
Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2491
Cellular senescence is a state of permanent cell cycle arrest in which a cell is unable to further divide in response to normal growth stimuli. Telomere shortening, believed ...

Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro

Thesis
Clift, M. J. D. Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2557
Quantum dots (QDs) are potentially advantageous tools for both diagnostics and therapeutics due to their light emitting characteristics. The impact of QDs on biological system...

Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency

Journal Article
Sanvisens, N., Romero, A. M., An, X., Zhang, C., de Llanos, R., Martinez-Pastor, M. T., …Puig, S. (2014)
Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency. Molecular and Cellular Biology, 34(17), 3259-3271. https://doi.org/10.1128/mcb.00472-14
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and ...

Palynological contribution to aerobiological studies in South-East Scotland.

Thesis
Caulton, E. Palynological contribution to aerobiological studies in South-East Scotland. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/6914
Airborne pollens and, more recently, spores, which occur in the rooftop airstream over Edinburgh have been monitored and the data analysed, since 1988. The thesis describes th...