Teaching Fellow and Lecturer in Biomedical Science
Smith, A., Moorhouse, E., Monaghan, J., Taylor, C., & Singleton, I. (in press). Sources and Survival of Listeria monocytogenes on Fresh, Leafy Produce. Journal of Applied Microbiology, ISSN 1364-5072
Listeria monocytogenes in an intracellular human pathogen which enters the body through contaminated food stuffs and is known to contaminate fresh leafy produce such as spinac...
Alegbeleye, O. O., Singleton, I., & Sant’Ana, A. S. (2018). Sources and contamination routes of microbial pathogens to fresh produce during field cultivation: A review. Food Microbiology, 73, (177-208). doi:10.1016/j.fm.2018.01.003. ISSN 0740-0020
Foodborne illness resulting from the consumption of contaminated fresh produce is a common phenomenon and has severe effects on human health together with severe economic and ...
Bridle, H., Kerrouche, A., & Desmulliez, M. (2018). Megasonic elution of waterborne protozoa enhances recovery rates. Science Matters, doi:10.19185/matters.201712000007. ISSN 2297-8240
Waterborne pathogens represent a major concern for human and animal health making monitoring of water essential to prevent outbreaks. Sample preparation is critical to assess ...
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.
Society for Reproduction and Fertility
SRF summer studentship
Scottish Funding Council
The aim of this project is to design and prototype a new, flatpack, low carbon home accessory for the Scottish tourist, domestic and export markets, using an eco-friendly alternative to medium density...
28 November 2017
20 April 2017
21 April 2017
The Biological Visualisation Community's 3rd Annual Meeting takes place at Craiglockhart Campus in Edinburgh on 20th-21st April 2017.
This two day meeting compri...
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, doi:10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLoS ONE, 12(5), (e0177653). doi:10.1371/journal.pone.0177653. ISSN 1932-6203
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Rees, C., Doyle, L., & Taylor, C. (2017). Listeria monocytogenes. In Foodborne Diseases, 253-276. (3rd). Elsevier. doi:10.1016/b978-0-12-385007-2.00012-7
Listeria monocytogenes was first described in 1923. Before 1982, L. monocytogenes was recognized as a cause of abortions and encephalitis in many animals (particularly cattle ...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Cham, Switzerland: Springer Verlag. doi:10.1007/978-3-319-32949-9_3
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Wani, S., Maker, J., Thompson, J., Barnes, J. & Singleton, I. (2015). Effect of Ozone Treatment on Inactivation of Escherichia coli and Listeria sp. on Spinach. Agriculture. 5(2), 155-169. doi:10.3390/agriculture5020155
The efficacy of “gaseous” ozone in reducing numbers and re-growth of food-borne pathogens, (Escherichia coli and Listeria spp.), on leafy salads was investigated using spinach...
Fraser, J. A. (2009). Regulation and Function of the Original p53- Inducible p21 Gene. In p53; Molecular Biology Intelligence Unit, 100-116. Springer Science + Business Media. doi:10.1007/978-1-4419-8231-5_7. ISBN 978-1-4419-8230-8; 978-1-4419-8231-5
P21 is a well known regulator of cell cycle progression through its inhibitory actions on Cyclin dependent kinases, (Cdk)/cyclin complexes, and DNA replication via its binding...
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), (80-89). doi:10.1016/j.taap.2007.07.012. ISSN 0041-008X
Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals ...
Bennett, H. J., Pearce, D. M., Glenn, S., Taylor, C. M., Kuhn, M., Sonenshein, A. L., …Roberts, I. S. (2007). Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence. Molecular Microbiology. 63, 1453--1467. doi:10.1111/j.1365-2958.2007.05597.x. ISSN 0950-382X
Listeria monocytogenes is a Gram-positive intracellular parasite and the causative organism of human listeriosis. In this article we demonstrate that L. monocytogenes encodes ...
Soddell, J. A., Stainsby, F. M., Eales, K. L., Seviour, R. J. & Goodfellow, M. (2006). Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. International Journal of Systematic and Evolutionary Microbiology. 56, 2265-2269. doi:10.1099/ijs.0.64034-0. ISSN 14665034
Three strains of non-motile, Gram-positive, filamentous actinomycetes, isolates J4T, J5 and J59, initially recognized microscopically in activated sludge foam by their distinc...
Lee, M., Kim, M., Singleton, I., Goodfellow, M., & Lee, S. (2006). Enhanced biodegradation of diesel oil by a newly identified Rhodococcus baikonurensis EN3 in the presence of mycolic acid. Journal of Applied Microbiology, 100(2), (325-333). doi:10.1111/j.1365-2672.2005.02756.x. ISSN 1364-5072
Aims: The aim of the present study was to isolate and characterize a bacterium, strain EN3, capable of using diesel oil as a major carbon and energy source, and to analyse th...
Taylor, C. M., Goldrick, M., Lord, L. & Roberts, I. S. (2005). Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. Journal of Bacteriology. 188(3), 1165-1168. doi:10.1128/JB.188.3.1165-1168.2006. ISSN 0021-9193
On the basis of increased resistance to K5 capsule-specific bacteriophage, a waaR transposon mutant defective in the biosynthesis of lipopolysaccharide outer core was isolated...
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms t...