Mick Rae
Mick Rae

Prof Mick Rae

Professor

Biography

Having begun my career at what was then Napier College of Commerce and Technology, then became Napier Polytechnic, I graduated in 1991 with an honours degree in Biological Sciences. This fostered an interest/obsession in the research field of reproduction, which I was fortunate to be able to pursue in the University of Edinburgh medical School, leading to the award of PhD in 1995. I then spent two years in the University of Kent working on projects examining novel cancer imaging techniques, which hugely boosted my laboratory skills, prior to returning to the field of reproductive sciences in 1997 at what is now the James Hutton Institute in Aberdeen. I returned to the University of Edinburgh in 2001, and remained there, working on ovarian function and cancer, until my initial appointment as a lecturer in Edinburgh Napier University. Becoming Reader in Reproductive Biology in 2012, I have continued to pursue my reproductive research interests, focusing upon the influence the prenatal environment has upon lifelong health – we are living longer, and ‘healthspan’ has to keep pace with lifespan if we are to maximise our quality of life, hence ensuring that we begin our lives with the best possible health opportunities for life is something I am very keen to contribute to.
In my spare time, I attempt to keep a classic car on the road, and enjoy fishing for wild brown trout all over Scotland.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Society for Reproduction and Fertility, Council member 2011-2015

 

Conference Organising Activity

  • Invited chair, University of Oxford SRF annual conference 2015 – session: ‘oocytes’
  • Lead organiser of National Ovarian Workshop 2005
  • Invited chair: University of Cambridge SRF annual conference 2014, session: plenary opening
  • Local organiser of the 2nd World Congress of Reproductive Biology, Edinburgh International Conference Centre, 2014
  • Invited chair: Royal Society of Edinburgh, Special conference in recognition of scientific contributions of Professor AS McNeilly, Ovary session 2014

 

Editorial Activity

  • Editorial board member

 

External Examining/Validations

  • External examination of PhD University of Southampton
  • University of Nottingham Veterinary School, external examiner for 2nd year of veterinary studies
  • PhD external examiner: University of Aberdeen, University of Nottingham

 

Fellowships and Awards

  • Honorary Fellow in the Deanery of Clinical Sciences, in the College of Medicine and Veterinary Medicine, The University of Edinburgh

 

Invited Speaker

  • How reproduction works (more or less)
  • Prenatal steroids programme metabolic dysfunction in sheep
  • Invited speaker at Perth Zoo, Australia
  • Invited speaker at Murdoch University
  • Invited speaker at INRA (Paris)
  • Invited speaker University of Edinburgh: ‘How to build an academic career’
  • Invited speaker at SRUC 2014 – ‘how biomedical and agricultural scientists can benefit from each other more’.

 

Reviewing

  • Ad hoc reviewer of scientific articles for numerous (>3) international journals

 

Date


65 results

Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion

Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., …Rae, M. T. (2016)
Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), https://doi.org/10.1038/srep27408
Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fet...

Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, May)
Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat. Paper presented at European Congress of Endocrinology

Altered adipocytes in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Couckan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2015, November)
Altered adipocytes in an ovine model of polycystic ovary syndrome. Poster presented at Society for Endocrinology BES

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

Presentation / Conference
Siemienowicz, K., Rae, M., Lerner, A., Franks, S., & Duncan, C. (2015, July)
Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Paper presented at Society for Reproduction and Fertility Annual Conference
Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance...

In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis.

Journal Article
Kanellopoulos-Langevin, C., Connolly, F., Rae, M. T., Späth, K., Boswell, L., McNeilly, A. S., & Duncan, W. C. (2015)
In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. PLOS ONE, 10, https://doi.org/10.1371/journal.pone.0132113
Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Othe...

The local effects of ovarian diathermy in an ovine model of Polycystic Ovary Syndrome

Journal Article
Shen, W., Connolly, F., Rae, M. T., Butler, M., Klibanov, A. L., Sboros, V., …Duncan, W. C. (2014)
The local effects of ovarian diathermy in an ovine model of Polycystic Ovary Syndrome. PLOS ONE, 9, https://doi.org/10.1371/journal.pone.0111280
In order to develop a medical alternative to surgical ovarian diathermy (OD) in polycystic ovary syndrome (PCOS) more mechanistic information is required about OD. We therefor...

Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Rae, M., & Duncan, C. (2014, September)
Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Paper presented at Society for Reproduction and Fertility Annual Conference, Edinburgh

Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response

Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2014)
Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), https://doi.org/10.1371/journal.pone.0102386
BACKGROUND Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Boswell, L., Carr, D., Mina, T., Connolly, F., Rae, M., & Duncan, C. (2014, May)
The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome. Poster presented at 16th European Congress of Endocrinology
Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hep...

Excess Androgens in Utero Alters Fetal Testis Development.

Journal Article
Connolly, F., Rae, M. T., Bittner, L., Hogg, K., McNeilly, A. S., & Duncan, W. C. (2013)
Excess Androgens in Utero Alters Fetal Testis Development. Endocrinology, 154, 1921-1933. https://doi.org/10.1210/en.2012-2153
Prenatal androgenization induces a polycystic ovary syndrome-like phenotype in adult female offspring, which is associated with alterations that can be detected in the fetal o...

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Reproductive and metabolic programming by exogenous steroids
  • Optimisation and validation of an in vitro bioassay as a tool for measuring Luteinising Hormone in several species of mammals