Lecturer in Biomedical Science
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2003). Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis, 245-258. ISBN 978-3-8167-6478-6
No abstract available.
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017). Carbon nanoparticles inhibit the antimicrobial activities of the human cathelicidin LL-37 through structural alteration. Journal of Immunology. doi:10.4049/jimmunol.1700706. ISSN 0022-1767
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides. doi:10.1016/j.peptides.2017.07.013. ISSN 0196-9781
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Consejo Superior de Investigaciones Científicas
The main goal of this project is to understand the mechanisms responsible for the virulence of food-related yeasts on humans, and to provide tools and recommendations to prevent the release of yeasts ...
Society of Applied Microbiology
sfam Student into work grant
Associate Professor of Immunology & Infection / Director of Research, School of Applied Sciences
Lecturer and Research Leader in Biomedical Sciences
Longbottom, D., Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., …Dalgleish, M. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLoS ONE. doi:10.1371/journal.pone.0177653. ISSN 1932-6203
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Sweet, M. J., Brown, B. E., Dunne, R. P., Singleton, I. & Bulling, M. (2017). Evidence for rapid, tidal related shifts in the microbiome of the coral Coelastrea aspera. Coral Reefs. doi:10.1007/s00338-017-1572-y. ISSN 0722-4028
Shifts in the microbiome of the intertidal coral Coelastrea aspera (formally known as Goniastrea aspera) from Phuket, Thailand were noted over the course of a four day period ...
Hakima, A. & Ian, S. (2017). Isolation of Indigenous Hydrocarbon Transforming Bacteria from Oil Contaminated Soils in Libya: Selection for Use as Potential Inocula for Soil Bioremediation. International Journal of Environmental Bioremediation and Biodegradation. 5(1), 8-17. doi:10.12691/ijebb-5-1-2
The Libyan oil industry has left a significant legacy of contamination and methods are required to remediate oil-contaminated soils in the area. In this work hydrocarbon utili...
Rees, C. E. D., Doyle, L. & Taylor, C. M. (2017). Listeria monocytogenes. In Foodborne Diseases, 253-276. (3rd). Elsevier. doi:10.1016/b978-0-12-385007-2.00012-7. ISBN 9780123850072
Listeria monocytogenes was first described in 1923. Before 1982, L. monocytogenes was recognized as a cause of abortions and encephalitis in many animals (particularly cattle ...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Dancer, S. J. (2016). Antibiotic prescribing: the consequences of getting it wrong. The Journal. 10(2), 62-71
Antibiotics were one of the most important discoveries last century. As with all drugs, however, they are associated with adverse effects. This article reviews how inappropria...
Dancer, S. J. (2016). Dos and don’ts for hospital cleaning. Current Opinion in Infectious Diseases. 29(4), 415-423. doi:10.1097/qco.0000000000000289. ISSN 0951-7375
Purpose of review: More evidence is emerging on the role of cleaning and decontamination for reducing hospital-acquired infection. Timely and adequate removal of environmental...
Barlow, P. G., Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., …Colin Duncan, W. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology. 117, 10-16. doi:10.1016/j.jri.2016.06.006. ISSN 0165-0378
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Sousa, F. H., Casanova, V., Stevens, C. & Barlow, P. G. (2016). Antiviral host defence peptides. In Epand, R. M. (Ed.). Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Springer. doi:10.1007/978-3-319-32949-9_3. ISBN 978-3-319-32947-5
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Storrie, S., Longbottom, D., Barlow, P. G. & Wheelhouse, N. (2016). MAPK activation is essential for Waddlia chondrophila induced CXCL8 expression in human epithelial cells. PLoS ONE. 11, e0152193. doi:10.1371/journal.pone.0152193. ISSN 1932-6203
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive
disease in humans and cattle. The organism is a member of the order Chla...
Wani, S., Maker, J., Thompson, J., Barnes, J. & Singleton, I. (2015). Effect of Ozone Treatment on Inactivation of Escherichia coli and Listeria sp. on Spinach. Agriculture. 5(2), 155-169. doi:10.3390/agriculture5020155
The efficacy of “gaseous” ozone in reducing numbers and re-growth of food-borne pathogens, (Escherichia coli and Listeria spp.), on leafy salads was investigated using spinach...
Barlow, P. G., Findlay, E. G., Currie, S. M. & Davidson, D. J. (2013). Antiviral potential of cathelicidins. Future Microbiology. 9, 55-73. doi:10.2217/fmb.13.135. ISSN 1746-0913
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of i...
MinION sequencing of bacterial isolates
SFAM students and graduates into work grant
University of Glasgow
Supporting Evidence Based Interventions
Biotechnology and Biological Sciences Research Council
Development of a UK-Brazil partnership to tackle fungal food spoilage and improve food security
Scottish Funding Council
The project objectives and scope are (i) to establish a knowledge base of current practice in starter culture use and possible bacteriophage-related issues in the artisanal cheese-making sector in Sco...