Research Output

Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy.

  A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this complication of diabetes. In the present study we investigated the expression of cannabinoid CB1 receptors in models of diabetic neuropathy. PC12 cells were differentiated into a neuronal phenotype with nerve growth factor (NGF, 50 ng/ml) in varying concentrations of glucose (5.5 to 50 mM). CB1 receptor expression was studied at the mRNA level by RT-PCR, and at the protein level via immunohistochemical and Western blot analysis. CB1 expression was also compared in dorsal root ganglia (DRG) removed from streptozotocin (STZ)-induced diabetic
rats versus control animals. Total neurite length induced by NGF was reduced in cells cultured in 20–50 mM glucose at day 6 (P

Citation

Zhang, F., Hong, S., Stone, V. & Smith, P. (2007). Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics. 323, 508-515. doi:10.1124/jpet.107.128272. ISSN 15210103

Keywords

Diabetes; Neuropathy; Cannabinoid CB1 receptors; Relationships;

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