Research Output

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation

  The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal phenotyping of male and female 6-week-old Oc-cre;Pdpnflox/flox (cKO) mice and their Pdpnflox/flox controls (fl/fl) has revealed that Pdpn deletion significantly compromises tibial cortical bone microarchitecture in both sexes, albeit to different extents (P

  • Type:

    Article

  • Date:

    08 May 2017

  • Publication Status:

    Accepted

  • ISSN:

    0021-9541

  • Library of Congress:

    RC1200 Sports Medicine

  • Dewey Decimal Classification:

    613 Personal health & safety

  • Funders:

    Biotechnology and Biological Sciences Research Council; Arthritis Research UK

Citation

Staines, K., Javaheri, B., Hohenstein, P., Fleming, R., Ikpegbu, E., Unger, E., …Farquharson, C. (in press). Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of Cellular Physiology. ISSN 0021-9541

Authors

Copyright

This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

Keywords

Osteocytes; E11; osteocalcin; osteoblasts; dendrite

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