Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment
Thesis
Ross, B. L. Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2404236
Reproduction is the only certain constant within animals and maintaining the integrity of this process is key to ensuring survival of the species. However, male fertility rate...
The effect of azathioprine on bone health
Thesis
Morgan, S. The effect of azathioprine on bone health. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2386593
Individuals with inflammatory bowel disease (IBD) often present with poor bone health and have increased risk of osteoporotic bone fractures. The development of targeted thera...
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019)
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9
Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular...
The role of the human cathelicidin LL-37 in rhinovirus infection
Thesis
Henderson Sousa, F. The role of the human cathelicidin LL-37 in rhinovirus infection. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2070903
Human rhinoviruses (HRVs) are the most common causes for symptomatic respiratory infections, and have been linked to severe respiratory conditions in children, and in immunoco...
The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway
Thesis
Hooper, K. The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2070992
Crohn’s disease (CD), one of the main forms of Inflammatory Bowel Disease (IBD), is a complex disorder characterised by chronic inflammation of the gastrointestinal (GI) tract...
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019)
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology...
The role of exercise in cancer rehabilation.
Presentation / Conference
Campbell, A. (2018, April)
The role of exercise in cancer rehabilation. Presented at Danish Physiotherapy Conference
No abstract available.
The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study
Journal Article
Dobson, C., Russell, A., Brown, S., & Rubin, G. (2018)
The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study. European Journal of Cancer Care, 27(2), https://doi.org/10.1111/ecc.12815
Prolonged diagnostic intervals are associated with poorer outcomes, and the patient interval appears to be a substantial contributor to the overall length of the diagnostic in...
Control of Antimicrobial Resistance Requires an Ethical Approach
Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...