Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia
Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...
New developments in osteoarthritis and cartilage biology
Journal Article
Poulet, B., & Staines, K. A. (2016)
New developments in osteoarthritis and cartilage biology. Current Opinion in Pharmacology, 28, 8-13. https://doi.org/10.1016/j.coph.2016.02.009
Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis. Characterised by articular cartilage loss, subchondral bone thickening and osteophyt...
A perspective on the developmental toxicity of inhaled nanoparticles.
Journal Article
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., …Cassee, F. R. (2015)
A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experim...
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015)
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211
Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosoph...
The Glycosylation of AGP and Its Associations with the Binding to Methadone
Journal Article
Behan, J. L., Cruickshank, Y. E., Matthews-Smith, G., Bruce, M., & Smith, K. D. (2013)
The Glycosylation of AGP and Its Associations with the Binding to Methadone. BioMed Research International, 2013, 1-7. https://doi.org/10.1155/2013/108902
Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of
explanation for the reports of its relatively low success ...
The well-being outcomes of career guidance
Journal Article
Robertson, P. J. (2013)
The well-being outcomes of career guidance. British Journal of Guidance and Counselling, 41(3), 254-266. https://doi.org/10.1080/03069885.2013.773959
The potential for career guidance to impact on well-being has received insufficient attention in the UK. There are both conceptual and empirical reasons to expect that the imp...
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status
Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012)
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020
Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the huma...
Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012)
Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852
The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target fo...
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012)
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143
The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and ma...