Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Key actions for a sustainable chemicals policy
Journal Article
Collins, C., Depledge, M., Fraser, R., Johnson, A., Hutchison, G., Matthiessen, P., …Sumpter, J. (2020)
Key actions for a sustainable chemicals policy. Environment International, 137, https://doi.org/10.1016/j.envint.2020.105463
Chemicals policies have spawned a wide range of regulations aimed at limiting damage to the environment and human health. Most instruments are reactive and fragmented. We prop...
Editorial
Journal Article
Hutchison, G. (2018)
Editorial. Ology: Reviews in Applied Sciences, 1, 3. https://doi.org/10.14297/ras.v1i1.5
Guest editorial for the inaugural issue of Ology.
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...
A perspective on the developmental toxicity of inhaled nanoparticles.
Journal Article
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., …Cassee, F. R. (2015)
A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experim...
Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy
Journal Article
Zhu, D., Farcal, L., Torres Andón, F., Di Cristo, L., Rotoli, B. M., Bussolati, O., …Fadeel, B. (2015)
Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy. PLOS ONE, 10, https://doi.org/10.1371/journal.pone.0127174
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was perfo...
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts
Journal Article
van den Driesche, S., McKinnell, C., Calarrão, A., Kennedy, L., Hutchison, G. R., Hrabalkova, L., …Mitchell, R. T. (2015)
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts. Environmental Health Perspectives, 123(3), 223-230. https://doi.org/10.1289/ehp.1408248
Background: Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the ste...
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.
Journal Article
Girardi, G., Fraser, J. A., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015)
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20, 1017-1026. https://doi.org/10.1038/mp.2014.110
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of
complement activation in placenta and foetal brain in vivo in u...
In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers.
Journal Article
Kermanizadeh, A., Pojana, G., Gaiser, B. K., Birkedal, R., Bilanicˇová, D., Wallin, H., …Stone, V. (2013)
In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology, 7, 301-313. https://doi.org/10.3109/17435390.2011.653416
Effects on the liver C3A cell line treated with a panel of engineered nanomaterials (NMs) consisting of two zinc oxide particles (ZnO; coated 100 nm and uncoated 130 nm), two ...
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ
Journal Article
Kermanizadeh, A., Brown, D. M., Hutchison, G. R., & Stone, V. (2012)
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ. Journal of Nanomedicine and Nanotechnology, 4, 157. https://doi.org/10.4172/2157-7439.1000157
Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), some
Nanomaterials (NMs) translocate to secondary tissues, prominently ...