Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment
Presentation / Conference
Male Reproductive Health and Advanced Bio-Nanomaterials: A focus on developing predictive assessment methods
Presentation / Conference
Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment
Presentation / Conference
Key actions for a sustainable chemicals policy
Journal Article
Collins, C., Depledge, M., Fraser, R., Johnson, A., Hutchison, G., Matthiessen, P., …Sumpter, J. (2020)
Key actions for a sustainable chemicals policy. Environment International, 137, https://doi.org/10.1016/j.envint.2020.105463
Chemicals policies have spawned a wide range of regulations aimed at limiting damage to the environment and human health. Most instruments are reactive and fragmented. We prop...
Editorial
Journal Article
Hutchison, G. (2018)
Editorial. Ology: Reviews in Applied Sciences, 1, 3. https://doi.org/10.14297/ras.v1i1.5
Guest editorial for the inaugural issue of Ology.
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk
assessment. The altered physico-chemical properties of ENM mean traditi...
A perspective on the developmental toxicity of inhaled nanoparticles.
Journal Article
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., …Cassee, F. R. (2015)
A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experim...