How to build a bone: PHOSPHO1, biomineralization and beyond
Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019)
How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), https://doi.org/10.1002/jbm4.10202
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role ...
Land use driven change in soil pH affects microbial carbon cycling processes
Journal Article
Malik, A. A., Puissant, J., Buckeridge, K. M., Goodall, T., Jehmlich, N., Chowdhury, S., …Griffiths, R. I. (2018)
Land use driven change in soil pH affects microbial carbon cycling processes. Nature Communications, 9(1), 1-10. https://doi.org/10.1038/s41467-018-05980-1
Soil microorganisms act as gatekeepers for soil–atmosphere carbon exchange by balancing the accumulation and release of soil organic matter. However, poor understanding of the...
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...
Relative age effects in international age group championships: A study of Spanish track and field athletes
Journal Article
Brazo-Sayavera, J., Martínez-Valencia, M. A., Müller, L., Andronikos, G., & Martindale, R. J. J. (2018)
Relative age effects in international age group championships: A study of Spanish track and field athletes. PLOS ONE, 13(4), https://doi.org/10.1371/journal.pone.0196386
The relative age effect is a well-researched phenomenon, however there is still a dearth of understanding in track and field and female sport. This study investigated the role...
Aqueous morpholine pre-treatment in cellulose nanofibril (CNF) production: comparison with carboxymethylation and TEMPO oxidisation pre-treatment methods
Journal Article
Onyianta, A. J., Dorris, M., & Williams, R. (2017)
Aqueous morpholine pre-treatment in cellulose nanofibril (CNF) production: comparison with carboxymethylation and TEMPO oxidisation pre-treatment methods. Cellulose, https://doi.org/10.1007/s10570-017-1631-0
In this study, pulped cellulose fibres were pre-treated with aqueous morpholine prior to mechanical disruption in the production of cellulose nanofibrils (CNF). The properties...
TetraploidSNPMap: Software for Linkage Analysis and QTL Mapping in Autotetraploid Populations Using SNP Dosage Data
Journal Article
Hackett, C. A., Boskamp, B., Vogogias, A., Preedy, K. F., & Milne, I. (2017)
TetraploidSNPMap: Software for Linkage Analysis and QTL Mapping in Autotetraploid Populations Using SNP Dosage Data. Journal of Heredity, 108(4), 438-442. https://doi.org/10.1093/jhered/esx022
An earlier software application of ours, TetraploidMap for Windows, enabled linkage analysis and quantitative trait locus interval mapping to be carried out in an experimental...
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., …Bou-Gharios, G. (2016)
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLOS ONE, 11(12), https://doi.org/10.1371/journal.pone.0167971
Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme f...
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., …Partridge, L. (2016)
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017
Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporte...
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function
Journal Article
Kerr, G. W., Wong, J. H., & Arumugam, P. (2016)
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function. Scientific Reports, 6(1), https://doi.org/10.1038/srep30397
PP2ACdc55 is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2ACdc55 activity...
Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion
Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., …Rae, M. T. (2016)
Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), https://doi.org/10.1038/srep27408
Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fet...