Research Output
Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone.
  During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

  • Type:

    Article

  • Date:

    30 November 2004

  • Publication Status:

    Published

  • Publisher

    Elsevier

  • DOI:

    10.1016/S0140-6736(05)74814-5

  • ISSN:

    0140-6736

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    579 Microorganisms, fungi & algae

Citation

Robinson, D. A., Kearns, A. M., Holmes, A., Morrison, D., Grundmann, H., Edwards, G., …Enright, M. C. (2004). Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone. Lancet. 365, 1256-1258. doi:10.1016/S0140-6736(05)74814-5. ISSN 0140-6736

Authors

Keywords

Staphylococcus aureus; phage type 80/81; hospital-acquired and community-acquired infections; penicillinase-resistant β lactams; MRSA:

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