Lecturer and Research Leader in Biomedical Sciences
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., …Stone, V. (2004). Nanoparticle and metal interactions and their impact on lung toxicology. In Proceedings of the Ninth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 48-50. ISBN 1 899110 88 7
No abstract available.
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2003). Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis, 245-258. ISBN 978-3-8167-6478-6
Hubbard, G., Taylor, C., Beeken, B., Campbell, A., Gracey, J., Grimmett, C., …Gorely, T. (2017). Research priorities about stoma- related quality of life from the perspective of people with a stoma: a pilot survey. Health expectations. , 1-7. doi:10.1111/hex.12585. ISSN 1369-6513
Background:There is a recognized need to include patients in setting research priorities. Research priorities identified by people with a stoma are rarely elicited.
Chief Scientists Office
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Society of Applied Microbiology
MinION sequencing of bacterial isolates
20 April 2017
21 April 2017
The Biological Visualisation Community's 3rd Annual Meeting takes place at Craiglockhart Campus in Edinburgh on 20th-21st April 2017.
This two day meeting compri...
Reader in Immunology & Infection / Director of Research, School of Applied Sciences
Chouliara, Z., Karatzias, T., Gullone, A., Ferguson, S. & Cosgrove, K. (2017). Therapeutic change from interpersonal trauma in group therapy: a relational framework for research and clinical practice. Journal of Interpersonal Violence. , 1-20. doi:10.1177/0886260517696860. ISSN 0886-2605
Our understanding of therapeutic change processes in group therapy for complex interpersonal trauma has been limited. The present study aimed at addressing this gap by develop...
Pegington, M., Adams, J. E., Bundred, N. J., Campbell, A., Howell, A., Howell, S. J., …Harvey, M. (2017). Recruitment to the “breast - activity and healthy eating after diagnosis” (B-AHEAD) randomized controlled trial. Integrative Cancer Therapies. 1-7doi:10.1177/1534735416687850. ISSN 1534-7354
Excess weight at breast cancer diagnosis and weight gain during treatment are linked to increased breast cancer specific and all-cause mortality. The Breast—Activity and Healt...
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports. 6, 37150. doi:10.1038/srep37150. ISSN 2045-2322
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E. & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology. doi:10.1113/ep085771. ISSN 0958-0670
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main findin...
Hubbard, G., O’Carroll, R., Munro, J., Mutrie, N., Haw, S., Mason, H. & Treweek, S. (2016). The feasibility and acceptability of trial procedures for a pragmatic randomised controlled trial of a structured physical activity intervention for people diagnosed with colorectal cancer: findings from a pilot trial of cardiac rehabilitation versus usual care (no rehabilitation) with an embedded qualitative study. Pilot and Feasibility Studies. 2(1)doi:10.1186/s40814-016-0090-y. ISSN 2055-5784
Background: Pilot and feasibility work is conducted to evaluate the operational feasibility and acceptability of the intervention itself and the feasibility and acceptability ...
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H. & Guy, K. (2008). Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity. 22(4), 544-551. doi:10.1016/j.bbi.2007.11.002. ISSN 0889-1591
Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antig...
Lin, Y., Stevens, C. & Hupp, T. (2007). Identification of a Dominant Negative Functional Domain on DAPK-1 That Degrades DAPK-1 Protein and Stimulates TNFR-1-mediated Apoptosis. Journal of Biological Chemistry. 282, 16792-16802. doi:10.1074/jbc.M611559200. ISSN 0021-9258
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., …Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry. 282, 13791-13803. doi:10.1074/jbc.M605649200. ISSN 0021-9258
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the me...
Taylor, C. M., Goldrick, M., Lord, L. & Roberts, I. S. (2005). Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. Journal of Bacteriology. 188(3), 1165-1168. doi:10.1128/JB.188.3.1165-1168.2006. ISSN 0021-9193
On the basis of increased resistance to K5 capsule-specific bacteriophage, a waaR transposon mutant defective in the biosynthesis of lipopolysaccharide outer core was isolated...
Wojcik, G., Kydonaki, C., Willis, D. & Williams, B. (2017, March). An integrative review of factors influencing the use of antibiotic de-escalation in hospital setting. Poster presented at Edinburgh Antimicrobial Resistance Research Symposium, Edinburgh
Coyle, C. (2014). The Roles and Expression of Cationic Host Defence Peptides in Normal and Compromised Pregnancies. (Thesis)
Cationic Host Defense Peptides (CHDP), also known as antimicrobial peptides, are key components of the host innate immune response that have a wide range of direct microbicida...