Research Output
Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression
  The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1, β3 and γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

  • Type:

    Article

  • Date:

    31 December 1994

  • Publication Status:

    Published

  • Publisher

    Ovid Technologies (Wolters Kluwer Health)

  • DOI:

    10.1097/00041444-199400430-00009

  • ISSN:

    0955-8829

  • Library of Congress:

    RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

  • Dewey Decimal Classification:

    612 Human physiology

Citation

Coon, H., Hicks, A. A., Bailey, M. E., Hoff, M., Holik, J., Harvey, R. J., …Byerley, W. (1994). Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatric Genetics, 4(3), 185-191. https://doi.org/10.1097/00041444-199400430-00009

Keywords

Genetics(clinical); Genetics; Biological Psychiatry; Psychiatry and Mental health

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