Fiona Kerr

fiona kerr

Dr Fiona Kerr

Lecturer

Biography

Dr Fiona Kerr is a Lecturer in Molecular Pharmacology at Edinburgh Napier University, with a focus on studying the molecular links between ageing and Alzheimer’s disease (AD). Previously, she undertook her PhD at the Institute of Psychiatry, Kings College London, investigating the connections between diabetes mellitus and AD pathology using cell culture and animal models, then spent 10 years as a Post-Doctoral Research Associate at the Institute of Health Ageing, University College London, where she investigated the role of longevity genes in preventing AD pathology using the fruit fly, Drosophila Melanogaster. As a Research Fellow at Glasgow Caledonian University, and now as lecturer at Edinburgh Napier, Fiona is leading her own research group, which aims to translate her findings to human systems using neuronal cell culture models. Her work has involved extensive collaborations nationally & internationally, and has been funded by a GCU Research Fellowship & PhD studentship, pilot funding from Tenovus Scotland & the ARUK Scotland Network, and Vacation Studentships from the Biochemical Society & the Wellcome Trust.

Outside of the lab Fiona is a member, and current Co-ordinator of the Alzheimer’s Research UK Scotland Network Centre, a Carnegie Research Trust Research Assessor (Science, Engineering & Technology Panel) and member of the Royal Society of Edinburgh Young Academy of Scotland. Finally, she is passionate about communicating science to a wide range of audiences, and has been actively involved in Public Engagement activities at the Royal Society, the Science Museum (London), and the British Library, as well as in the local community as part of Glasgow Science Festival and GCU Community Science Day events.

Themes

Research Areas

Esteem

Grant Funding Panel Member

  • Carnegie Trust (Science Engineering & Technology) Panel Member

 

Membership of Professional Body

  • European Crucible Member
  • Royal Society of Edinburgh Young Academy of Scotland Member
  • Alzheimer's Research UK Scotland Network Centre Organising Committee Member

 

Research Degree External Examining

  • PhD Examiner University of St Andrews
  • Postgraduate Research (MRes) Examiner Lancaster University
  • Postgraduate Research (MRes) Examiner Lancaster University

 

Date


18 results

Building a Systematic Online Living Evidence Summary of COVID-19 Research

Journal Article
Hair, K., Sena, E. S., Wilson, E., Currie, G., Macleod, M., Bahor, Z., …Drury, B. (in press)
Building a Systematic Online Living Evidence Summary of COVID-19 Research. Journal of the European Association for Health Information and Libraries, 17(2), 21-26. https://doi.org/10.32384/jeahil17465
Throughout the global coronavirus pandemic, we have seen an unprecedented volume of COVID-19 researchpublications. This vast body of evidence continues to grow, making it diff...

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity

Journal Article
Niccoli, T., Kerr, F., Snoeren, I., Fabian, D., Aleyakpo, B., Ivanov, D., …Partridge, L. (2021)
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications, 3(2), https://doi.org/10.1093/braincomms/fcab053
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer’s disease. However, the precise mechanisms mediating their neurotoxicity are unclear...

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

Journal Article
Scholes, H. M., Cryar, A., Kerr, F., Sutherland, D., Gethings, L. A., Vissers, J. P. C., …Thalassinos, K. (2020)
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-74748-9
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Unders...

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

Journal Article
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018)
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Frontiers in Molecular Neuroscience, 11, https://doi.org/10.3389/fnmol.2018.00297
Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium’s effectiveness for improving ne...

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Journal Article
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Gomez Perez-Nievas, B., Bertrand, H. C., …Partridge, L. (2017)
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genetics, 13(3), https://doi.org/10.1371/journal.pgen.1006593
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease...

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., …Partridge, L. (2016)
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017
Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporte...

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

Journal Article
Castillo-Quan, J., Li, L., Kinghorn, K., Ivanov, D., Tain, L., Slack, C., …Partridge, L. (2016)
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports, 15(3), 638-650. https://doi.org/10.1016/j.celrep.2016.03.041
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approv...

Deletion of endogenous Tau proteins is not detrimental in Drosophila

Journal Article
Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., …Partridge, L. (2016)
Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports, 6, https://doi.org/10.1038/srep23102
Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical fil...

A holidic medium for Drosophila melanogaster

Journal Article
Piper, M. D. W., Blanc, E., Leitão-Gonçalves, R., Yang, M., He, X., Linford, N. J., …Partridge, L. (2014)
A holidic medium for Drosophila melanogaster. Nature methods, 11(1), 100-105. https://doi.org/10.1038/nmeth.2731
A critical requirement for research using model organisms is a well-defined and consistent diet. There is currently no complete chemically defined (holidic) diet available for...

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

Journal Article
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012)
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLOS ONE, 7(7), https://doi.org/10.1371/journal.pone.0040569
Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the d...

Current Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • PhD Supervisor (Secondary) Glasgow Caledonian University
  • PhD Supervisor (Primary) Glasgow Caledonian University