Fiona Kerr

fiona kerr

Dr Fiona Kerr

Lecturer

Biography

Dr Fiona Kerr is a Lecturer in Molecular Pharmacology at Edinburgh Napier University, with a focus on studying the molecular links between ageing and Alzheimer’s disease (AD). Previously, she undertook her PhD at the Institute of Psychiatry, Kings College London, investigating the connections between diabetes mellitus and AD pathology using cell culture and animal models, then spent 10 years as a Post-Doctoral Research Associate at the Institute of Health Ageing, University College London, where she investigated the role of longevity genes in preventing AD pathology using the fruit fly, Drosophila Melanogaster. As a Research Fellow at Glasgow Caledonian University, and now as lecturer at Edinburgh Napier, Fiona is leading her own research group, which aims to translate her findings to human systems using neuronal cell culture models. Her work has involved extensive collaborations nationally & internationally, and has been funded by a GCU Research Fellowship & PhD studentship, pilot funding from Tenovus Scotland & the ARUK Scotland Network, and Vacation Studentships from the Biochemical Society & the Wellcome Trust.

Outside of the lab Fiona is a member, and current Co-ordinator of the Alzheimer’s Research UK Scotland Network Centre, a Carnegie Research Trust Research Assessor (Science, Engineering & Technology Panel) and member of the Royal Society of Edinburgh Young Academy of Scotland. Finally, she is passionate about communicating science to a wide range of audiences, and has been actively involved in Public Engagement activities at the Royal Society, the Science Museum (London), and the British Library, as well as in the local community as part of Glasgow Science Festival and GCU Community Science Day events.

Themes

Research Areas

Esteem

Grant Funding Panel Member

  • Carnegie Trust (Science Engineering & Technology) Panel Member

 

Membership of Professional Body

  • European Crucible Member
  • Royal Society of Edinburgh Young Academy of Scotland Member
  • Alzheimer's Research UK Scotland Network Centre Organising Committee Member

 

Research Degree External Examining

  • PhD Examiner University of St Andrews
  • Postgraduate Research (MRes) Examiner Lancaster University
  • Postgraduate Research (MRes) Examiner Lancaster University

 

Date


19 results

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

Journal Article
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012)
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLOS ONE, 7(7), https://doi.org/10.1371/journal.pone.0040569
Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the d...

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

Journal Article
Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., …Partridge, L. (2010)
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease. PLoS Genetics, 6(9), https://doi.org/10.1371/journal.pgen.1001087
Aβ peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylati...

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

Journal Article
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism, 11(1), 35-46. https://doi.org/10.1016/j.cmet.2009.11.010
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms includi...

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

Journal Article
Kerr, F., Augustin, H., Piper, M. D. W., Gandy, C., Allen, M. J., Lovestone, S., & Partridge, L. (2011)
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiology of Aging, 32(11), 1977-1989. https://doi.org/10.1016/j.neurobiolaging.2009.10.015
Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (A...

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Journal Article
Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., …Lovestone, S. (2009)
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochemical and Biophysical Research Communications, 386(1), 257-262. https://doi.org/10.1016/j.bbrc.2009.06.032
As impaired insulin signalling (IIS) is a risk factor for Alzheimer's disease we crossed mice (Tg2576) over-expressing human amyloid precursor protein (APP), with insulin rece...

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Journal Article
Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S., & Brandner, S. (2007)
Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella. Molecular and Cellular Neuroscience, 34(3), 400-408. https://doi.org/10.1016/j.mcn.2006.11.014
Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN a...

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3

Journal Article
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006)
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Letters, 580(13), 3121-3128. https://doi.org/10.1016/j.febslet.2006.04.064
Deregulation of PTEN/Akt signalling has been recently implicated in the pathogenesis of Alzheimer's disease (AD), but the effects on the molecular processes underlying AD path...

School Students as Drosophila Experimenters

Journal Article
Siyad, F., Griffiths, J., Janjua, F., Jackson, E., Rodrigues, I., Kerr, F., …Lovestone, S. (2005)
School Students as Drosophila Experimenters. PLoS Biology, 3(7), https://doi.org/10.1371/journal.pbio.0030246
School students as Drosophila experimenters.

Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease

Journal Article
Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., …Lovestone, S. (2004)
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neuroscience Letters, 373(1), 1-4. https://doi.org/10.1016/j.neulet.2004.10.031
Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. As increasing evidence has suggested a role for glyco...

Current Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • PhD Supervisor (Secondary) Roxanna Munir, Glasgow Caledonian University
  • PhD Supervisor (Primary) Mohamed Elsharkasi, Glasgow Caledonian University