Jenny Fraser

Jenny Fraser

Dr Jenny Fraser BSc (Hons), PhD, FHEA

Lecturer

Biography

Dr Jenny Fraser BSc (Hons) PhD FHEA is a Lecturer and Principal Investigator within the School of Applied Sciences at Edinburgh Napier University.

She completed her BSc (Hons) in Pharmacology at the University of Aberdeen in 1998 and her PhD studying the post-translational regulation of glutamate cysteine ligase (GCL) at the University of Dundee in 2002, with Dr Lesley McLellan. She completed her 1st Postdoctoral Research position in Dr McLellan’s lab, investigating GCL regulation and aging in Drosophila melanogaster.

In 2004, she moved to the Edinburgh Cancer Research Centre within the University of Edinburgh's Institute of Genetics & Molecular Medicine (IGMM), working as a Postdoctoral Researcher within the Cell Signalling Laboratory of Professor Ted Hupp. Here she worked on the importance of phosphorylation and Mdm2 dependant ubiquitination in regulating the function of the p53 tumour suppressor gene. She also investigated death-associated protein kinase (DAPK) signalling pathways. In 2011, Dr Fraser moved to Edinburgh Napier University, to undertake a Post Doctoral position within the nanosafety group, working with Dr Gary Hutchison. During this time, Jenny secured funding from Tenovus (Scotland) and worked as a zero hours lecturer within the school. In 2013, Jenny was appointed as a Lecturer in Biomedical sciences.

At Napier, Dr Fraser’s academic role focuses on research and teaching of undergraduate and postgraduate degrees. Jenny is an active member of the research community. Dr Fraser is interested in the biological mechanisms through which cells adapt to survive under stressful conditions. In particular, she is interested in the biochemical adaptations which occur as a result of reduced oxygen availability, or hypoxia. Her research focusses on the following areas:

1. Tumour adaptation to hypoxic stress and how altered gene expression and cellular metabolism may drive oncogenic protein glycosylation.
2. The importance of hypoxic adaptation, and Hif dependant signalling in ischaemic stroke

Dr Fraser has strong collaborative links at Edinburgh Napier University with Dr Amy Poole and they have shared and productive research interests in ischaemic stroke and neuroendocrine signalling in tumours.

She also has an active collaboration with Professor Arsenio Lopez at the University of Leon, Spain and Dr Lisa Pang at Edinburgh University's Royal (Dick) School of Veterinary Studies.

Esteem

Public Engagement Activity

  • STEM ambassador; various events in and around Edinburgh and the Lothians

 

Invited Speaker

  • Fraser JA, Fleet G, Hutchison G and Hupp TR (2011). Generating single chain antibodies towards the GLUT1 and GLUT3 glucose transporters; novel biomarkers for neoplastic transformation and tools for drug targeting and receptor inhibition (Oral presentatio
  • Fraser JA, Hutchison G and Hupp TR (2012). Generating single chain antibodies towards the GLUT1 and GLUT3 glucose transporters; (Oral presentation). 3rd RECAMO joint meeting on the role of p53, MDM2, AGR2/3 and ubiquitin/chaperone system in tumour biolo

 

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