Jenny Fraser

Jenny Fraser

Dr Jenny Fraser BSc (Hons), PhD, FHEA

Lecturer

Biography

Dr Jenny Fraser BSc (Hons) PhD FHEA is a Lecturer and Principal Investigator within the School of Applied Sciences at Edinburgh Napier University.

She completed her BSc (Hons) in Pharmacology at the University of Aberdeen in 1998 and her PhD studying the post-translational regulation of glutamate cysteine ligase (GCL) at the University of Dundee in 2002, with Dr Lesley McLellan. She completed her 1st Postdoctoral Research position in Dr McLellan’s lab, investigating GCL regulation and aging in Drosophila melanogaster.

In 2004, she moved to the Edinburgh Cancer Research Centre within the University of Edinburgh's Institute of Genetics & Molecular Medicine (IGMM), working as a Postdoctoral Researcher within the Cell Signalling Laboratory of Professor Ted Hupp. Here she worked on the importance of phosphorylation and Mdm2 dependant ubiquitination in regulating the function of the p53 tumour suppressor gene. She also investigated death-associated protein kinase (DAPK) signalling pathways. In 2011, Dr Fraser moved to Edinburgh Napier University, to undertake a Post Doctoral position within the nanosafety group, working with Dr Gary Hutchison. During this time, Jenny secured funding from Tenovus (Scotland) and worked as a zero hours lecturer within the school. In 2013, she was appointed as a Lecturer in Biomedical sciences.

At Napier, Dr Fraser’s academic role focuses on research and teaching of undergraduate and postgraduate degrees. She is an active member of the research community. Dr Fraser is interested in the biological mechanisms through which cells adapt to survive under conditions of stress. In particular, she is interested in the biochemical adaptations which occur as a result of reduced oxygen availability, or hypoxia. She is also interested in cancer cell biology and the drivers of oncogenic growth.

Dr Fraser has strong collaborative links at Edinburgh Napier University with Dr Amy Poole and they have shared and productive research interests in ischaemic stroke and neuroendocrine signalling in tumours. Her interest in hypoxia has also lead to new collaborative projects with researchers working on inflammatory bowel disease and tissue transplantation/reperfusion injury.

Dr Fraser also has external collaborations with Professor Arsenio Lopez at the University of Leon, Spain and Dr Lisa Pang at Edinburgh University's Royal (Dick) School of Veterinary Studies.

Esteem

Invited Speaker

  • Fraser JA, Fleet G, Hutchison G and Hupp TR (2011). Generating single chain antibodies towards the GLUT1 and GLUT3 glucose transporters; novel biomarkers for neoplastic transformation and tools for drug targeting and receptor inhibition (Oral presentatio
  • Fraser JA, Hutchison G and Hupp TR (2012). Generating single chain antibodies towards the GLUT1 and GLUT3 glucose transporters; (Oral presentation). 3rd RECAMO joint meeting on the role of p53, MDM2, AGR2/3 and ubiquitin/chaperone system in tumour biolo

 

Public Engagement Activity

  • STEM ambassador; various events in and around Edinburgh and the Lothians

 

Date


20 results

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

Journal Article
Meehan, J., Gray, M., Martínez-Pérez, C., Kay, C., Pang, L. Y., Fraser, J. A., …Turnbull, A. K. (2020)
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00628
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunatel...

hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen

Journal Article
Fraser, J. A., Sutton, J. E., Tazayoni, S., Bruce, I., & Poole, A. V. (2019)
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-55665-y
Neuroendocrine prostate cancer (NEPC) is thought to arise as prostate adenocarcinoma cells transdifferentiate into neuroendocrine (NE) cells to escape potent anti-androgen the...

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia

Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following

Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...

Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis

Journal Article
Fraser, J. A., Worrall, E. G., Lin, Y., Landre, V., Pettersson, S., Blackburn, E., …Hupp, T. R. (2015)
Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis. Journal of Molecular Biology, 427(8), 1728-1747. https://doi.org/10.1016/j.jmb.2014.12.011
Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp17 stimulates MDM2-mediated polyubiquitination of p53. ...

Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.

Journal Article
Girardi, G., Fraser, J. A., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015)
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20, 1017-1026. https://doi.org/10.1038/mp.2014.110
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in u...

In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome

Conference Proceeding
Girardi, G., Fraser, J., Bertolaccini, M. L., Lennen, R., Vontell, R., & Hutchison, G. (2014)
In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome. https://doi.org/10.1016/j.placenta.2014.06.184
Objectives: To use MRI-based methods to non invasively detect placental insufficiency and predict fetal outcomes in obstetric antiphospholipid syndrome (APS) Methods and resul...

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