Katherine Staines

katherine staines

Dr Katherine Staines

Vice Chancellor's Research Fellow

Biography

Katherine Staines is a Vice Chancellor's Research Fellow at Edinburgh Napier University. Her research looks to understand the development, regulation and pathology of the musculoskeletal system, with a particular focus on understanding the molecular pathogenesis of osteoarthritis. Katherine's current research is funded by the Medical Research Council & Medical Research Scotland, and her group consists of a PDRA (Dr Jasmine Samvelyan), three PhD students (David Hughes, Rachel Lopera-Burgueno, Lewis Hsu) and an MRes student (Stephanie Morgan).

Katherine completed her BSc in Anatomical Sciences at Bristol University in 2008. Katherine then moved to the University of Edinburgh and was awarded her PhD in 2012, with a thesis that examined the role of Mepe in chondrocyte matrix mineralisation, under the direction of Prof. Colin Farquharson.

In 2012, Katherine started her first postdoctoral position with Prof. Andy Pitsillides at the Royal Veterinary College, London. It was during this Arthritis Research UK funded post that Katherine's interest in osteoarthritis developed. In 2014, Katherine moved back to the University of Edinburgh to work on another Arthritis Research UK postdoctoral position looking at the subchondral bone in osteoarthritis.

Katherine is in the European Calcified Tissue Society (ECTS) Academy, and currently sits on the Editorial Board for the Journal of Endocrinology, the Journal of Molecular Endocrinology, BMC musculoskeletal disorders, and Frontiers in Endocrinology, Bone Research. Katherine has reviewed papers for more than 25 different internationally-recoginsed journals, and has reviewed grants for a number of funding bodies including the Rosetrees Trust, the ECTS, and the Belgian Public Research Programme. Katherine's research has featured as a number of press releases including:

“Technology networks awarded £3million to solve life science challenges” – MRC News
“A bone to pick” – Laboratory News
“Showcasing the best in Diamond Science” – Materials World
“RVC study investigates progression of osteoarthritis” – Vet Times
“RVC Skeletal Biology Group’s work showcased in Diamond Light Source Annual Review Launch” – Royal Veterinary College Press Release
“Diamond unveils plans to ensure the UK maintains strong position of world science stage” – Diamond Light Source Press Release

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Bone Research Society New Investigator Representative (Basic)

 

Conference Activity

  • Organiser of the Bone Research Society Annual Conference, New Investigator session
  • Organiser of the ImagingBioPro Edinburgh kickoff meeting
  • Organiser of the ImagingBioPro Manchester workshop
  • Chair of the Bone Research Society Annual conference symposium: The Judith Adams Imaging Symposium: From Mice to Men
  • Chair of ECTS plenary oral presentations
  • Chair of the ECTS new investigator mentoring session
  • Organiser of the Edinburgh Musculoskeletal Group Monthly Research Symposiums
  • Organiser of the - Bone Research Society/BORS Basic Training Course in Bone and Cartilage Biology
  • Chair of the Bone Research Society/BORS Basic Training Course in Bone and Cartilage Biology
  • Chair of the Bone Research Society Annual Conference, Plenary lecture
  • Chair of the Bone Research Society Annual Conference, Oral communications
  • Organiser of the Bone Research Society Annual Conference, New Investigator session
  • Chair of the Bone Research Society/British Society for Matrix Biology conference, BRS Oral communications
  • Bone Research Society/British Society for Matrix Biology conference organising committee
  • Chair of the Bone Research Society Annual Conference Symposium: ‘What have the engineers ever done for us?’
  • Chair of The Easter Bush Research Consortium monthly seminars to foster communication between three research institutes
  • Poster presentations at national and international conferences, >25
  • Oral presentations at national and international conferences, >20

 

Editorial Activity

  • Editorial Board member for the Journal of Endocrinology
  • Editorial board member for the Journal of Molecular Endocrinology
  • Editorial Board member for BMC Musculoskeletal Disorders
  • Editorial board member for Frontiers in Endocrinology, Bone Research

 

Fellowships and Awards

  • Principal's Research Excellence Award, Edinburgh Napier University
  • Elected to the European Calcified Tissue Society Academy
  • New Investigator Award, Bone Research Society
  • ASBMR John Haddad Young Investigator Award
  • Bone Research Society Snowmass Award
  • Best oral presentation, Bone Research Society/British Orthopaedic Research Society joint meeting
  • Finalist selected for presentation at SET for Britain, Houses of Parliament
  • Presenter bursary, British Society of Matrix Biology
  • New Investigator Award, Osteoporosis and Bone Conference
  • Student Research Day, The University of Edinburgh, third prize winner
  • The Society for Endocrinology Postgraduate Essay prize runner up
  • UK Centre for bioscience Student Award
  • Student Research Day, The University of Edinburgh, first prize winner

 

Grant Reviewer

  • ECTS Fellowships
  • Belgian Public Research Programme
  • ASBMR Awards committee
  • ECTS Fellowships
  • Rosetrees Trust

 

Invited Speaker

  • Understanding pathological ossification in osteoarthritis, Manchester Met University
  • Understanding pathological ossification in osteoarthritis, IGMM, University of Edinburgh
  • Dynamic synchrotron imaging of osteoarthritic joints, Edinburgh Musculoskeletal Group Winter symposium
  • Public Engagement for health sciences, EastBio Health symposium, Edinburgh
  • Understanding pathological ossification in osteoarthritis. University of Brighton
  • Understanding pathological ossification in osteoarthritis, AIMM-ASBMR Young Investigators Meeting, Colorado USA
  • MicroCT analysis of subchondral bone thickening in osteoarthritis. University of Sheffield
  • Pathological ossification in osteoarthritis, University of Sheffield
  • Understanding pathological ossification in osteoarthritis; a major healthcare burden in the ageing population, EastBio Ageing symposium, Edinburgh
  • Sclerostin: An innate protector against osteoarthritic bone pathology, Royal Veterinary College, London

 

Media Activity

  • “Technology networks awarded £3million to solve life science challenges” – MRC News
  • "A bone to pick" - Laboratory News 14th March 2017
  • “Showcasing the best in Diamond Science” – Materials World 2nd August 2016
  • “RVC study investigates progression of osteoarthritis” – Vet Times 7th July 2016
  • “RVC Skeletal Biology Group’s work showcased in Diamond Light Source Annual Review Launch” – Royal Veterinary College Press Release 6th July 2016
  • “Diamond unveils plans to ensure the UK maintains strong position of world science stage” – Diamond Light Source Press Release 27th June 2016

 

Reviewing

  • Manuscript reviewer for >25 different journals

 

Date


36 results

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway

Journal Article
Chen, Z., Gordillo-Martinez, F., Jiang, L., He, P., Hong, W., Wei, X., …Zhu, D. (in press)
Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovascular Research, https://doi.org/10.1093/cvr/cvaa090
Aims Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic ...

Models of osteoarthritis: relevance and new insights

Journal Article
Samvelyan, H., Hughes, D., Stevens, C., & Staines, K. A. (in press)
Models of osteoarthritis: relevance and new insights. Calcified Tissue International, https://doi.org/10.1007/s00223-020-00670-x
Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most commo...

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020)
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40(1), https://doi.org/10.1042/BSR20190329
E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modeling/remodeling, throug...

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

Journal Article
Morgan, S., Hooper, K. M., Milne, E. M., Farquharson, C., Stevens, C., & Staines, K. A. (2019)
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease. International Journal of Molecular Sciences, 20(23), https://doi.org/10.3390/ijms20236085
Patients with inflammatory bowel disease (IBD) often present poor bone health and are 40% more at risk of bone fracture. Studies have implicated autophagy in IBD pathology and...

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., …Lee, P. (2020)
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and len...

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential

Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5(February 2020), https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019)
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9
Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular...

How to build a bone: PHOSPHO1, biomineralization and beyond

Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019)
How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), https://doi.org/10.1002/jbm4.10202
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role ...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...

The Ex Vivo Organ Culture of Bone

Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019)
The Ex Vivo Organ Culture of Bone. In Bone Research Protocols, 199-215. Humana Press Springer. doi:10.1007/978-1-4939-8997-3_10
The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of ...

Pre-Napier Funded Projects

  • Does deregulated PHOSPHO1 expression contribute to catabolic bone loss in hyper-parathyroid hormone disorders? Society for Endocrinology Summer Studentship; £2850 (Co-applicant)
  • Does deregulated PHOSPHO1 expression contribute to catabolic bone loss in hyper-parathyroid hormone disorders? Medical Research Scotland Vacation Scholarship; £2k (Co-applicant)
  • Investigating new therapeutic strategies for osteoarthritis. Tenovus Scotland small research grant; £12k
  • Generation of sclerostin knockout mice to examine sclerostin's functional role in endochondral bone growth and osteoarthritis. Society for Endocrinology Early Career Grant; £10k
  • In situ hybridisation of MEPE in the murine growth plate. European Calcified Tissue Society exchange grant; €2.5k

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Lewis Hsu, PhD supervision (University of Edinburgh)
  • Ekele Ikpegbu PhD supervision (University of Edinburgh)