Matthew Boyles
matthew boyles

Dr Matthew Boyles BSc (Hons), PhD

Lecturer

 0131 455 3372

  M.Boyles2@napier.ac.uk

  

Biography

Dr Matthew Boyles is a lecturer of Biomedical Sciences within the School of Applied Sciences at Edinburgh Napier University (ENU), Scotland, UK.
Matthew attained a BSc (Hons) in Biomedical Science in 2007 from ENU, and his PhD studying the toxicity and potential pathogenicity of high-performance engineered multi-walled carbon nanotubes in 2011, also from ENU.
Since, Matthew worked for four years at the BioNano Interactions, Human Immunity, Molecular Immunology research group in Salzburg University, Austria, as a Marie Curie Fellow within the EU FP7 ITN NanoTOES, and as a post-doctoral researcher on the EU FP7 consortium Nanovalid. This was followed by a two-year post-doctoral position at Heriot-Watt University, Edinburgh, Scotland, working on an industry funded project investigating health implications pertaining to in vitro exposure to various materials of the man-made fibre industry. Directly before joining ENU as a lecturer, Matthew worked as a consultant at the Institute of Occupational Medicine in Scotland for over six years, first as Senior Toxicologist and then as Research Team Lead of the Hazardous Materials Group.
Matthew’s research interests focus on the human hazard assessment of nanomaterials and other advanced materials. This includes understanding the mechanisms of toxicity induced by these materials, as well as the development and optimisation of New Approach Methodologies (NAMs) to help improve the reliability and application of in vitro techniques; improved methodologies will enable industry and regulators to better cope with the increasing hazard assessment demands of new technologies, and will reduce the reliance on in vivo testing.

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Research Groups

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Advisory panels and expert committees or witness

  • External advisory board member of EU project .

 

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13 results

Safe(r)-by-design principles in the thermoplastics industry: guidance on release assessment during manufacture of nano-enabled products

Journal Article
McLean, P., Hanlon, J., Salmatonidis, A., Galea, K. S., Brooker, F., Citterio, C., Magni, D., Vázquez-Campos, S., Lotti, D., & Boyles, M. S. P. (2024)
Safe(r)-by-design principles in the thermoplastics industry: guidance on release assessment during manufacture of nano-enabled products. Frontiers in Public Health, 12, https://doi.org/10.3389/fpubh.2024.1398104
Background: The application of nanomaterials (NMs) and nano-enabled products (NEPs) across many industries has been extensive and is still expanding decades after first being ...

A comparison of dermal toxicity models; assessing suitability for safe(r)-by-design decision-making and for screening nanomaterial hazards

Journal Article
McLean, P., Marshall, J., García, A., Beal, D., Katsumiti, A., Carrière, M., & Boyles, M. (2024)
A comparison of dermal toxicity models; assessing suitability for safe(r)-by-design decision-making and for screening nanomaterial hazards. Toxicology in Vitro, 97, Article 105792. https://doi.org/10.1016/j.tiv.2024.105792
The objective of Safe-by-Design (SbD) is to support the development of safer products and production processes, and enable safe use throughout a materials' life cycle; an inte...

Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure

Journal Article
Di Cristo, L., Janer, G., Dekkers, S., Boyles, M., Giusti, A., Keller, J. G., Wohlleben, W., Braakhuis, H., Ma-Hock, L., Oomen, A. G., Haase, A., Stone, V., Murphy, F., Johnston, H. J., & Sabella, S. (2022)
Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology, 16(3), 310-332. https://doi.org/10.1080/17435390.2022.2085207
Exposure to different nanoforms (NFs) via the dermal route is expected in occupational and consumer settings and thus it is important to assess their dermal toxicity and the c...

Bayesian based similarity assessment of nanomaterials to inform grouping

Journal Article
Tsiliki, G., Ag Seleci, D., Zabeo, A., Basei, G., Hristozov, D., Jeliazkova, N., Boyles, M., Murphy, F., Peijnenburg, W., Wohlleben, W., & Stone, V. (2022)
Bayesian based similarity assessment of nanomaterials to inform grouping. NanoImpact, 25, Article 100389. https://doi.org/10.1016/j.impact.2022.100389
Nanoforms can be manufactured in plenty of variants by differing their physicochemical properties and toxicokinetic behaviour which can affect their hazard potential. To avoid...

Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages

Journal Article
Pang, C., Neubauer, N., Boyles, M., Brown, D., Kanase, N., Hristozov, D., Fernandes, T., Stone, V., Wohlleben, W., & Marcomini, A. (2017)
Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages. NanoImpact, 7, 75-83. https://doi.org/10.1016/j.impact.2017.06.002
Nanoscale copper phthalocyanine (n-CuPc) is a pigment widely used in paints to enhance automobile coatings and to make colors transparent and more appealing to users. Despite ...

A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells

Journal Article
Frijns, E., Verstraelen, S., Stoehr, L. C., Van Laer, J., Jacobs, A., Peters, J., Tirez, K., Boyles, M. S. P., Geppert, M., Madl, P., Nelissen, I., Duschl, A., & Himly, M. (2017)
A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells. Environmental Science and Technology, 51(9), 5259-5269. https://doi.org/10.1021/acs.est.7b00493
A new prototype air–liquid interface (ALI) exposure system, a flatbed aerosol exposure chamber termed NAVETTA, was developed to investigate deposition of engineered nanopartic...

Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles

Journal Article
Piret, J.-P., Bondarenko, O. M., Boyles, M. S. P., Himly, M., Ribeiro, A. R., Benetti, F., Smal, C., Lima, B., Potthoff, A., Simion, M., Dumortier, E., Leite, P. E. C., Balottin, L. B., Granjeiro, J. M., Ivask, A., Kahru, A., Radauer-Preiml, I., Tischler, U., Duschl, A., Saout, C., …Toussaint, O. (2017)
Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles. Archives of Toxicology, 91(6), 2315-2330. https://doi.org/10.1007/s00204-016-1897-2
The rapid development of nanotechnologies and increased production and use of nanomaterials raise concerns about their potential toxic effects for human health and environment...

An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine

Book Chapter
Boyles, M. S., Powell, L. G., Kermanizadeh, A., Johnston, H. J., Rothen-Rutishauser, B., Stone, V., & Clift, M. J. (2017)
An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. In Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production (443-468). Wiley. https://doi.org/10.1002/9783527800681.ch18
Nanotechnology, considered an industrial revolution occurring across the twentieth and twenty first centuries, promises to provide numerous advantages to both humans and the e...

Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells

Journal Article
Stoehr, L. C., Madl, P., Boyles, M. S. P., Zauner, R., Wimmer, M., Wiegand, H., Andosch, A., Kasper, G., Pesch, M., Lütz-Meindl, U., Himly, M., & Duschl, A. (2015)
Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells. Environmental Science and Technology, 49(14), 8721-8730. https://doi.org/10.1021/acs.est.5b02503
Air pollution is associated with increased risk of cardiovascular and pulmonary diseases, but conventional air quality monitoring gives no information about biological consequ...

Carbon nanotube–cellular interactions: macrophages, epithelial and mesothelial cells

Book Chapter
Stone, V., Kermanizadeh, A., Johnston, H., Boyles, M., & Varet, J. (2012)
Carbon nanotube–cellular interactions: macrophages, epithelial and mesothelial cells. In K. Donaldson, C. Poland, R. Duffin, & J. Bonner (Eds.), . Cambridge University Press. https://doi.org/10.1017/cbo9780511919893.010

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