Melanie Leggate

Melanie Leggate

Dr Melanie Leggate

Lecturer

Biography

My research interests include the effects of physical activity and exercise on risk factors for long-term chronic diseases, particularly those related to ageing, obesity, the metabolic syndrome, diabetes and cardiovascular disease. Chronic low-grade inflammation is a common link between these disease and many others and I am interested in how exercise can alter metabolic and inflammatory proteins in disease states.
I am particularly interested in the added health benefits that may be achieved by taking part in high intensity intermittent training, including changes in body composition, metabolism and markers of inflammation in healthy and ‘at risk’ populations.
Other research that I am involved in has looked at the role of ageing and vitamin D status. This research has focused on the link between physical activity status and vitamin D, and if there is a role of ageing and exercise on vitamin D concentration and vitamin D receptor expression.

Themes

Esteem

Grant Reviewer

  • Invited grant assessor for Diabetes UK

 

Invited Speaker

  • Conference talk: Leggate M, Carter WG, Nimmo MA (2011) Levels of inflammatory proteins in subcutaneous adipose tissue and the circulation, in response to 2 weeks of high intensity intermittent training. 16th Annual Congress of the ECSS, Liverpool, UK
  • Leggate M, 4th International Sport Sciences Symposium for Active Life (ISSSAL) (2011) The response of adipokines/myokines to acute and chronic high intensity interval training. Waseda University, Japan. Invited Speaker

 

Reviewing

  • Applied Physiology, Nutrition, and Metabolism
  • Diabetes, Obesity and Metabolism
  • International Journal of Sport Nutrition & Exercise Metabolism

 

Date


11 results

Exercise Window Trial in Newly Diagnosed Breast Cancer–Letter

Journal Article
Sims, A. H., Leggate, M., & Campbell, A. (2019)
Exercise Window Trial in Newly Diagnosed Breast Cancer–Letter. Clinical Cancer Research, 25(24), 7609-7610. https://doi.org/10.1158/1078-0432.ccr-19-2571

The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults

Journal Article
Lithgow, H. M., Florida-James, G., & Leggate, M. (2018)
The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults. Physiological Reports, 6(9), https://doi.org/10.14814/phy2.13684
High intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently...

The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults

Journal Article
Lithgow, H., & Leggate, M. (2018)
The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults. International Journal of Exercise Science, 11(3), 95-105
Our aim was to investigate the acute effects of a single bout of high intensity intermittent training (HIIT) on glucose tolerance and other physiological and metabolic markers...

Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms

Journal Article
Khan, J. N., Wilmot, E. G., Leggate, M., Singh, A., Yates, T., Nimmo, M., …McCann, G. P. (2014)
Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms. European heart journal cardiovascular Imaging, 15(11), 1263-1269. https://doi.org/10.1093/ehjci/jeu121
Aims To assess the cardiac, vascular, anthropometric, and biochemical determinants of subclinical diastolic dysfunction in younger adults with Type 2 diabetes mellitus (T2DM) ...

Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction

Journal Article
Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., …Davies, M. J. (2014)
Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic medicine : a journal of the British Diabetic Association, 31(7), 794-798. https://doi.org/10.1111/dme.12431
Aim A pilot study to phenotype young adults (Methods Twenty people with Type 2 diabetes (aged 18–40 years), 10 lean and 10 obese control subjects underwent detailed assessme...

Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men

Journal Article
Patterson, S. D., Leggate, M., Nimmo, M. A., & Ferguson, R. A. (2013)
Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. European Journal of Applied Physiology, 113, 713-719. https://doi.org/10.1007/s00421-012-2479-5
It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); ...

The effect of physical activity on mediators of inflammation

Journal Article
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013)
The effect of physical activity on mediators of inflammation. Diabetes, obesity & metabolism, 15(s3), 51-60. https://doi.org/10.1111/dom.12156
Being physically active and undertaking exercise on a regular basis are critical lifestyle behaviours which protect against the development of numerous chronic metabolic condi...

Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males

Journal Article
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012)
Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology, 112, 1353-1360. https://doi.org/10.1152/japplphysiol.01080.2011
This study aimed to determine whether 2 wk of high-intensity intermittent training (HIIT) altered inflammatory status in plasma and adipose tissue in overweight and obese male...

The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling

Journal Article
Leggate, M., Nowell, M. A., Jones, S. A., & Nimmo, M. A. (2010)
The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones, 15, 827-833. https://doi.org/10.1007/s12192-010-0192-z
As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study in...

Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization

Journal Article
Barwell, N. D., Malkova, D., Leggate, M., & Gill, J. M. R. (2009)
Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism, 58, 1320-1328. https://doi.org/10.1016/j.metabol.2009.04.016
Fat loss in response to exercise training varies between individuals, even when differences in compliance to the exercise program are accounted for. The purpose of this study ...

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