Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections
Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September)
Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece
Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Red...
The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections
Presentation / Conference Contribution
Oluwadare, E., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2015, August)
The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites IX, Hydra, Greece
Billions of livestock, and a third of the current human population, are infected with helminth parasites. In livestock, these helminth infections are accompanied by significan...
Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens
Presentation / Conference Contribution
Sehgal, A., Hutchison, G., Proudfoot, L., Malone, E., Cameron, P., & Fraser-Pitt, D. (2012, July)
Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens. Poster presented at Society for Applied Microbiology Summer Conference: Resistance, Adaptation and Bioremediation, Edinburgh
Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity
Presentation / Conference Contribution
Nicol, L., Malone, E., & Proudfoot, L. (2012, April)
Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity. Poster presented at British Society for Parasitology Conference, 50th Anniversary, Glasgow
Nanomaterials, having at least one dimension less than 100nm, have unique physico-chemical properties due to their small size, large surface area and surface reactivity. Manuf...
Nanoparticles and Neutrophil Activation
Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February)
Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland
Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are t...