Research Output

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells

  New Findings
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main finding and its importance?
Our study reveals that TANG cells are redistributed into the circulation in response to acute strenuous exercise, but to a lesser extent than CD31− T cells. Of the TANG cells mobilized, TANG cells expressing CXCR4 show greater redistribution compared with CXCR4− TANG cells. Stromal-derived factor 1-α does not appear to play a role in the redistribution of TANG cells expressingCXCR4. The results suggest that a single bout of strenuous exercise might provide a short vasculogenic window, which could benefit the vascular systemby redistributing CD31+ TANG cells.

  • Type:

    Article

  • Date:

    01 September 2016

  • Publication Status:

    Published

  • Publisher

    Wiley-Blackwell

  • DOI:

    10.1113/ep085771

  • ISSN:

    0958-0670

  • Library of Congress:

    RC1200 Sports Medicine

  • Dewey Decimal Classification:

    613 Personal health & safety

Citation

Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), (1253-1264). doi:10.1113/ep085771. ISSN 0958-0670

Authors

Keywords

angiogenic cells, exercise, CXCR4, T cells,

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