Research Output
Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation
  The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis.

  • Type:

    Article

  • Date:

    19 June 2012

  • Publication Status:

    Published

  • Publisher

    Wiley-Blackwell

  • DOI:

    10.1002/cbf.2852

  • ISSN:

    0263-6484

  • Library of Congress:

    RM Therapeutics. Pharmacology

  • Dewey Decimal Classification:

    615 Pharmacology and therapeutics

Citation

Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852

Authors

Keywords

Wnt signaling pathway, chondrogenesis, joint homeostasis, endochondral ossification, osteoarthritis,

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