Research Output
Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial
  INTRODUCTION: Results from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial suggest hearing intervention may not reduce 3‐year cognitive decline in all older adults with hearing loss but may be beneficial in certain groups. This secondary analysis investigated if participants with multiple risk factors for cognitive decline received greater benefits. METHODS: We used a sample of dementia‐free participants (N = 2692) from the Atherosclerosis Risk in Communities (ARIC) cohort to develop a predictive model for cognitive decline. The model was applied to baseline measures of ACHIEVE participants (N = 977) to estimate predicted risk. We tested an interaction between predicted risk and randomization to hearing intervention or health education control. RESULTS: Among ACHIEVE participants in the top quartile of predicted risk, 3‐year cognitive decline in the hearing intervention was 61.6% (95% confidence interval [CI]: 33.7%–94.1%) slower than the control. DISCUSSION: The effect of hearing intervention on reducing 3‐year cognitive decline was greatest among individuals with multiple baseline risk factors associated with faster cognitive decline. Trial Registration: ClinicalTrials.gov Identifier: NCT03243422 Highlights: The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial tested the effect of hearing intervention on cognitive decline. Participants were recruited from the Atherosclerosis Risk in Communities (ARIC) cohort or de novo from the local community. A 48% reduction in cognitive decline was observed in ARIC cohort participants. In this secondary analysis, there was an interaction between hearing intervention and predicted risk of cognitive decline. Among participants in the top quartile of predicted risk of cognitive decline, hearing intervention slowed cognitive decline by 62%.

  • Date:

    01 May 2025

  • Publication Status:

    Published

  • DOI:

    10.1002/alz.70156

  • ISSN:

    1552-5260

  • Funders:

    National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute of Deafness and Other Communication Disorders; Neurocognitive data were collected using U.S. National Institutes of Health grants; National Institute of Neurological Disorders and Stroke; National Institute on Aging

Citation

Pike, J. R., Huang, A. R., Reed, N. S., Arnold, M., Chisolm, T., Couper, D., Deal, J. A., Glynn, N. W., Goman, A. M., Hayden, K. M., Mitchell, C. M., Pankow, J. S., Sanchez, V., Sullivan, K. J., Tan, N. S., Coresh, J., & Lin, F. R. (2025). Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 21(5), e70156. https://doi.org/10.1002/alz.70156

Authors

Keywords

aging, hearing aids, hearing, dementia, hearing loss, randomized control trial, cognitive decline, presbycusis, cognition, memory

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