Research Output

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction

  Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalling, the additional protein interaction domains of DAPK are relatively ill defined. This review will summarize our current knowledge of the DAPK interactome, the use of peptide aptamers to define novel protein–protein interaction motifs, and how these new protein–protein interactions give insight into DAPK functions in diverse cellular processes, including growth factor signalling, the regulation of autophagy, and its emerging role in the regulation of immune responses.

  • Type:

    Article

  • Date:

    30 October 2009

  • Publication Status:

    Published

  • Publisher

    Wiley

  • DOI:

    10.1111/j.1742-4658.2009.07411.x

  • ISSN:

    1742-464X

  • Library of Congress:

    QR180 Immunology

  • Dewey Decimal Classification:

    571 Physiology & related subjects

  • Funders:

    The University of Edinburgh

Citation

Lin, Y., Hupp, T. R., & Stevens, C. (2009). Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), (48-57). ISSN 1742-464X

Authors

Keywords

autophagy; DAPK; growth factor; immune response; interactome; kinase; mTOR; peptide

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