Research Output
Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer
  Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the α2 mRNA appears to be confined to the Bergmann glial cell layer. The α3 mRNA is only expressed in the Golgi cells. This differential distribution of {GABAA} receptor mRNA subtypes suggests a previously unrecognized complexity of {GABAergic} transmission in the cerebellum.

  • Type:

    Article

  • Date:

    30 November 1989

  • Publication Status:

    Published

  • DOI:

    10.1016/0304-3940(89)90193-6

  • Cross Ref:

    0304394089901936

  • ISSN:

    0304-3940

  • Library of Congress:

    RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

  • Dewey Decimal Classification:

    612 Human physiology

Citation

Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

Keywords

In situ hybridization, Cerebellum, γ-Aminobutyric acid-A receptor, Bergmann glia,

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