Research Output
FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression
  E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis) however the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated osteocytogenesis and to reveal the nature of the underlying signaling pathways regulating this process. Exposure of MC3T3 osteoblast-like cells and murine primary osteoblasts to FGF-2 (10ng/ml) increased E11 mRNA and protein expression (P

  • Type:

    Article

  • Date:

    07 December 2017

  • Publication Status:

    Published

  • DOI:

    10.1002/jcp.26345

  • ISSN:

    0021-9541

  • Library of Congress:

    QP Physiology

  • Dewey Decimal Classification:

    612 Human physiology

  • Funders:

    Arthritis Research UK; Biotechnology and Biological Sciences Research Council; Tertiary Education Trust Fund Nigeria (TETFund)

Citation

Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., …Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

Authors

Keywords

Osteocytes, osteoblasts, E11/podoplanin, FGF-2, osteocytogenesis.

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