Research Output
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel
  Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridization to the Xq27–q28 region. Employing somatic hybrid cell lines with human X chromosome breakpoints within this region, we performed a fine mapping of the gene within Xq28. Our results indicate that the biglycan gene is proximal to the red/green cone pigment genes, G6PD, and coagulation factor {VIII} and is distal to DXS304, DXS305, and GABRA3. The biglycan gene precisely maps to a region of the X chromosome, where, by comparative gene mapping, one would expect to find the gene for X-linked dominant chondrodysplasia punctata/ichthyosis/short stature (Happle) syndrome. Hence, {BGN} is a candidate gene for the Happle syndrome.

  • Type:

    Article

  • Date:

    30 June 1992

  • Publication Status:

    Published

  • DOI:

    10.1016/0888-7543(92)90279-2

  • Cross Ref:

    0888754392902792

  • ISSN:

    0888-7543

  • Library of Congress:

    QH426 Genetics

  • Dewey Decimal Classification:

    576 Genetics & evolution

Citation

Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., …Ropers, H. (1992). Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2

Keywords

Genetics

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