Research Output
High-level vancomycin-resistant enterococci causing hospital infections
  Nosocomial infection or colonization due to enterococci with high-level
resistance to vancomycin (minimal inhibitory concentrations [MICs] between 64
and > 2000 mg/L) has occurred in 41 patients with renal disease. These
vancomycin-resistant enterococci were cultured from many sources including
blood. All but one strain contained one or more plasmids ranging in molecular
weight from 1*0 to 40 Megadaltons (MDa). Vancomycin resistance was transferable
by conjugation to a susceptible recipient strain of Enterococcus faecalis but this
was not always associated with plasmid DNA. The emergence of transferable highlevel
vancomycin resistance in enterococci causing significant clinical infections is
of particular importance since vancomycin is widely regarded as a reserve drug for
the management of infections with multi-resistant Gram-positive organisms.

  • Type:

    Article

  • Date:

    31 December 1989

  • Publication Status:

    Published

  • Publisher

    Cambridge University Press

  • DOI:

    10.1017/S0950268800030478

  • Cross Ref:

    S0950268800030478

  • ISSN:

    0950-2688

  • Library of Congress:

    QR Microbiology

  • Dewey Decimal Classification:

    579 Microorganisms, fungi & algae

Citation

Uttley, A. H. C., George, R. C., Naidoo, J., Woodford, N., Johnson, A. P., Collins, C. H., …Heptonstall, J. (1989). High-level vancomycin-resistant enterococci causing hospital infections. Epidemiology and Infection, 103(01), 173-181. https://doi.org/10.1017/S0950268800030478

Authors

Keywords

Enterococci; vancomycin; minimal inhibitory concentrations (MICs);

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