Immunomodulatory effects of cannabinoids in human T-lymphocytes

Research Output

Background: Circulating levels of endocannabinoids are elevated in obese and hyperglycaemic patients and may contribute to immune dysfunction in obesity and diabetes. Cannabinoids have been shown to evoke both pro-and anti-inflammatory responses, acting via CB 1 and CB 2 receptors on immune cells. In the present study we compared the responses of human T-cells to varying concentrations (0.1–1000nM) of endocannabinoids (anandamide and 2-arachidonoylglycerol, 2-AG), a phytocannabinoid (Δ 9-tetrahydrocannabinol, Δ 9-THC), and a synthetic CB 2 receptor agonist (JWH-015).

Date:

15 November 2009
Publication Status:

Published
Library of Congress:

QR180 Immunology
Dewey Decimal Classification:

615 Pharmacology and therapeutics
Funders:

Edinburgh Napier Funded

http://researchrepository.napier.ac.uk/output/1155509 <p>Schinwald, A., Galban-Horcajo, F., Malone, E., & Smith, P. (2009). Immunomodulatory effects of cannabinoids in human T-lymphocytes. In <i>Proceedings of the British Pharmacological Society</i></p>

Citation

Schinwald, A., Galban-Horcajo, F., Malone, E., & Smith, P. (2009). Immunomodulatory effects of cannabinoids in human T-lymphocytes. In Proceedings of the British Pharmacological Society