Research Output

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease

  Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology involves a combination of genetic and environmental factors resulting in abnormal immune responses to intestinal microbiota. Genetic studies have strongly linked genes involved in autophagy to CD, and genes involved in the unfolded protein response (UPR) to IBD. The UPR is triggered in response to accumulation of misfolded proteins in the endoplasmic reticulum (ER) and autophagy plays a key role to relieve ER-stress and restore homeostasis. This review summarises the known interactions between autophagy and the UPR and discusses the impact of these converging pathways on IBD pathogenesis. With a paucity of effective long-term treatments for IBD, targeting of synergistic pathways may provide novel and more effective therapeutic options.

  • Type:

    Review

  • Date:

    24 December 2018

  • Publication Status:

    Published

  • Publisher

    Oxford University Press (OUP)

  • DOI:

    10.1093/ibd/izy380

  • ISSN:

    1078-0998

  • Library of Congress:

    RC Internal medicine

  • Dewey Decimal Classification:

    617 Surgery & related medical specialties

  • Funders:

    National Health Service Research Scotland Career Researcher Fellowship; Crohn’s in Childhood Research Association

Citation

Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (in press). Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, doi:10.1093/ibd/izy380

Authors

Keywords

IBD, autophagy, unfolded protein response, ER stress

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    This is a pre-copyedited, author-produced version of an article accepted for publication in inflammatory Bowel Disease following peer review. The version of recordHooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (in press). Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, doi:10.1093/ibd/izy380 is available online at: https://doi.org/10.1093/ibd/izy380

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