Research Output

Revisiting the Central and Peripheral Immune System

  The idiotypic network has a long and chequered history in both theoretical immunology and Artificial Immune Systems. In terms of the latter, the drive for engineering applications has led to a diluted interpretation of the immunological models. Research inspired by theoretical immunology has produced compelling models of self-organised tolerance and immunity, but currently fail to have any practical engineering applicability. In this paper, we briefly discuss the engineering applicability of “self-affirming” idiotypic networks, leading to a suggestion that the “Third Generation” network models represent a way forward in this respect. Results obtained by implementing and extending a discrete model of this type of network suggest that the extended prototype is capable of two context-dependent modes of immune response, readily applicable to unsupervised machine-learning.

  • Date:

    31 December 2007

  • Publication Status:


  • Publisher


  • DOI:


  • Library of Congress:

    QA75 Electronic computers. Computer science

  • Dewey Decimal Classification:

    006.3 Artificial intelligence


McEwan, C., Hart, E., & Paechter, B. (2006). Revisiting the Central and Peripheral Immune System. In Artificial Immune Systems. ICARIS 2007, 240-251. doi:10.1007/978-3-540-73922-7_21



Artificial immune systems; theoretical immunology; “self-affirming” idiotypic networks; “Third Generation” network;

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