Research Output
Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography
  Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using split-dose Single Photon Emission Tomography (SPET or SPECT) with 99mTc-Exametazime. All patients suffered from unipolar depressive illness and were rated on the Newcastle scale and with the 17-item Hamilton scale. They completed tests of orientation and verbal memory on the day of ECT. For comparison, verbal memory was also tested on the preceding day. The uptake of 99mTc-Exametazime was expressed relative to calcarine/occipital cortex. Significant decreases in tracer uptake were confined to the inferior anterior cingulate cortex. The changes were correlated with the severity of depressive symptoms and more weakly with decrements of memory function produced by ECT; there was no significant correlation with stimulus intensity or electroencephalographic measures of seizure duration.

  • Type:

    Article

  • Date:

    31 December 1993

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

    10.1016/0165-0327(94)90148-1

  • Cross Ref:

    0165032794901481

  • ISSN:

    0165-0327

  • Library of Congress:

    RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

  • Dewey Decimal Classification:

    616.8 Nervous & mental disorders

Citation

Scott, A. I. F., Dougall, N., Ross, M., O'Carroll, R. E., Riddle, W., Ebmeier, K. P. & Goodwin, G. M. (1993). Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders. 30(1), 27-34. doi:10.1016/0165-0327(94)90148-1. ISSN 0165-0327

Authors

Keywords

Electroconvulsive therapy; Electroconvulsive shock; Unipolar depressive illness; SPECT; Exametazime; Cingulate cortex

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