Research Output

Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients

  Background Enhancing biological resilience may offer a novel way to prevent and ameliorate disease in older patients. We investigated whether changes in C-reactive protein (CRP), as a dynamic marker of the acute inflammatory response to diverse stressors, may provide a way to operationalize the concept of resilience in older adults. We tested this hypothesis by examining whether such changes could predict prognosis by identifying which individuals are at greater risk of 6-month mortality. Methods Analysis of prospective, routinely collected datasets containing data on hospitalization, clinical chemistry and rehabilitation outcomes for rehabilitation inpatients between 1999 and 2011. Maximum CRP response during acute illness and CRP recovery indices (time and slope of CRP decay to half maximum, and to

  • Type:

    Article

  • Date:

    02 July 2016

  • Publication Status:

    Published

  • Publisher

    Public Library of Science (PLoS)

  • DOI:

    10.1371/journal.pone.0159412

  • ISSN:

    1932-6203

  • Library of Congress:

    WT 100 Geriatrics

  • Dewey Decimal Classification:

    616 Diseases

  • Funders:

    Dundee Clinical Academic Track; British Geriatrics Society; Chief Scientist Office, Scottish Government

Citation

Barma, M., Goodbrand, J. A., Donnan, P. T., McGilchrist, M. M., Frost, H., McMurdo, M. E. T., & Witham, M. D. (2016). Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients. PLOS ONE, 11(7), https://doi.org/10.1371/journal.pone.0159412

Authors

Keywords

General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine

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