Research Output
SPR biosensor based on polymer multi-mode optical waveguide and nanoparticle signal enhancement
  We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 × 10−3 RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform.

  • Type:

    Article

  • Date:

    20 May 2020

  • Publication Status:

    Published

  • DOI:

    10.3390/s20102889

  • Funders:

    Edinburgh Napier Funded

Citation

Gabriela Walter, J., Eilers, A., Alwis, L., Wilhelm Roth, B., & Bremer, K. (2020). SPR biosensor based on polymer multi-mode optical waveguide and nanoparticle signal enhancement. Sensors, 20(10), https://doi.org/10.3390/s20102889

Authors

Keywords

surface plasmon resonance (SPR); sensor; planar-optical; multi-mode; waveguide; biosensor; aptamer; gold-nanoparticle; lab-on-a-chip

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