Research Output

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes

  Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is preceded by endothelial dysfunction, which carries with it a proatherothrombotic phenotype. Endothelial senescence and reduced production and release of nitric oxide (NO) are associated with “vascular ageing” and are often accompanied by a reduced ability for the body to repair vascular damage, termed “reendothelialization.” Exercise has been repeatedly shown to confer protection against CVD and diabetes risk and incidence. Regular exercise promotes endothelial function and can prevent endothelial senescence, often through a reduction in oxidative stress. Recently, endothelial precursors, endothelial progenitor cells (EPC), have been shown to repair damaged endothelium, and reduced circulating number and/or function of these cells is associated with ageing. Exercise can modulate both number and function of these cells to promote endothelial homeostasis. In this review we look at the effects of advancing age on the endothelium and these endothelial precursors and how exercise appears to offset this “vascular ageing” process.

  • Type:

    Article

  • Date:

    01 January 2016

  • Publication Status:

    Published

  • Publisher

    Hindawi Publishing Corporation

  • DOI:

    10.1155/2016/3583956

  • Cross Ref:

    3583956

  • ISSN:

    1942-0900

  • Library of Congress:

    RC1200 Sports Medicine

  • Dewey Decimal Classification:

    612 Human physiology

Citation

Ross, M. D., Malone, E., & Florida-James, G. (2015). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, (1-15). doi:10.1155/2016/3583956. ISSN 1942-0900

Authors

Keywords

Vascular ageing; exercise;

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