Students into Work

  Salmonella enterica is a leading cause of foodborne infection with a recent increase in the number of antibiotic resistant isolates. We propose a biotechnological approach to the development of novel antimicrobial prodrug therapy which exploits the Salmonella outer membrane protease PgtE. PgtE is similar to MMP-9 in humans, and can degrade tissues of the extracellular matrix including collagen and gelatin. We are investigating the ability of recombinant PgtE to cleave a novel antimicrobial prodrug which contains a MMP-9-like cleavage domain. Cleavage of the domain would release active drug antibiotic) in the vicinity of PgtE.

  • Start Date:

    1 June 2014

  • End Date:

    31 October 2014

  • Activity Type:

    Externally Funded Research

  • Funder:

    Society of Applied Microbiology

  • Value:

    £2717

Project Team