Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise
Journal Article
Campbell, J. P., Guy, K., Cosgrove, C., Florida-James, G., & Simpson, R. J. (2008)
Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain, Behavior, and Immunity, 22(3), 375-380. https://doi.org/10.1016/j.bbi.2007.09.001
Cytotoxic T-lymphocytes co-express the T-cell receptor, CD3 and the MHC I restricted antigen CD8. Although total CD8 expression is often used to identify CD8+ T-cells in blood...
An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis.
Journal Article
Brown, D. M., Kinloch, I. A., Bangert, U., Windle, A., Walter, D. M., Walker, G. S., …Stone, V. (2007)
An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. Carbon, 45, 1743-1756. https://doi.org/10.1016/j.carbon.2007.05.011
There has been little information to date based on the potential health effects and hazards associated with the inhalation of carbon nanofibrous materials by workers despite t...
The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists.
Journal Article
Brown, D. M., Hutchison, L., Donaldson, K. & Stone, V. (2007)
The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. American journal of physiology. Lung cellular and molecular physiology. 292, L1444-L1451. doi:10.1152/ajplung.00162.2006. ISSN 1522-1504
We have previously examined the ability of air pollution particles (PM10) to promote release of the proinflammatory cytokine tumor necrosis factor- (TNF-) from human periphera...
The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4
Journal Article
Brown, D. M., HUTCHISON, L., DONALDSON, K., MACKENZIE, S., DICK, C., & STONE, V. (2007)
The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4. Toxicology Letters, 168(1), 1-6. doi:10.1016/j.toxlet.2006.10.016
Reactive oxygen species (ROS) have been implicated in various pulmonary diseases by causing direct injury to lung epithelial cells. Signalling activity of cells through transc...
Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium.
Journal Article
Moller, W., Brown, D. M., Kreyling, L., & Stone, V. (2005)
Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium. Particle and fibre toxicology, 2, 7. https://doi.org/10.1186/1743-8977-2-7
Background
Particulate air pollution is reported to cause adverse health effects in susceptible individuals. Since most of these particles are derived form combustion processe...
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo.
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005)
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933
Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main ...
Effects of PM10 in human peripheral blood monocytes and J774 macrophages.
Journal Article
Brown, D. M., Donaldson, K., & Stone, V. (2004)
Effects of PM10 in human peripheral blood monocytes and J774 macrophages. Respiratory Research, 5, 29. https://doi.org/10.1186/1465-9921-5-29
The effects of PM10, one of the components of particulate air pollution, was investigated using human monocytes and a mouse macrophage cell line (J774). The study aimed to inv...
Interactions between ultrafine particles and transition metals in vivo and in vitro.
Journal Article
Wilson, M. R., Lightbody, J., Donaldson, K., Sales, J., & Stone, V. (2002)
Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicology and Applied Pharmacology, 184, 172-179. https://doi.org/10.1006/taap.2002.9501
Both the ultrafine particle and transition metal components of particulate air pollution (PM10) have been hypothesized to be important factors in determining toxicity and pote...
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation.
Journal Article
McNeil, K. S., Knox, D. P. & Proudfoot, L. (2002)
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. Parasite Immunology. 24, 15-22. doi:10.1046/j.0141-9838.2001.00428.x. ISSN 0141-9838
Migration of L3 larvae of Nippostrongylus brasiliensis through the lungs of the rat, during primary infection, was studied at 24 h, 72 h and 8 days. At 24 h p.i., there was ev...
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
Journal Article
Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., & Donaldson, K. (2001)
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 175, 191-199. https://doi.org/10.1006/taap.2001.9240
Studies into the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM10) are as...