The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures
Journal Article
Houston, D. A., Myers, K., MacRae, V. E., Staines, K. A., & Farquharson, C. (2016)
The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures. Calcified Tissue International, 99(5), 510-524. https://doi.org/10.1007/s00223-016-0176-9
Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, are catabolic to bone. The increase in the RANKL/OPG ratio in response to c...
Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy
Journal Article
Zhang, F., Hong, S., Stone, V., & Smith, P. (2007)
Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics, 323, 508-515. https://doi.org/10.1124/jpet.107.128272
A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this comp...
Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008)
Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y
Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiov...
Role of androgens in fetal testis development and dysgenesis.
Journal Article
Scott, H. M., Hutchison, G. R., Mahood, I. K., Hallmark, N., Welsh, M., De Gendt, K., …Sharpe, R. M. (2007)
Role of androgens in fetal testis development and dysgenesis. Endocrinology. 148, 2027-2036. doi:10.1210/en.2006-1622. ISSN 0013-7227
This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely...
Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity
Journal Article
Fraser, J. A., & Hupp, T. R. (2007)
Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j
Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesi...
Thyroid hormone signaling in human ovarian surface epithelial cells.
Journal Article
Rae, M. T., Gubbay, O., NaKostogiannou, A., Price, D., Critchley, H. O. D. & Hillier, S. G. (2007)
Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism. 92, 322-327. doi:10.1210/jc.2006-1522. ISSN 0021-972X
Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectivel...
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis
Journal Article
Keir, P. A., Brown, D. M., Clouter-Baker, A., Harcus, Y. M., & Proudfoot, L. (2004)
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26(3), 137-139. https://doi.org/10.1111/j.0141-9838.2004.00692.x
It has been reported that excretory–secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune syst...
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases.
Journal Article
Anderson, N. E., Pollacchi, A., Hayes, P., Therapondos, G., Newsome, P., Boyter, A. & Smith, K. (2002)
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography. 16, 365-372. doi:10.1002/bmc.167. ISSN 0269-3879
During the acute phase response (APR) to tissue injury or infection, the liver is responsible for the level of mediators such as cytokines required at the site of inflammation...