PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function
Journal Article
Kerr, G. W., Wong, J. H., & Arumugam, P. (2016)
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function. Scientific Reports, 6(1), https://doi.org/10.1038/srep30397
PP2ACdc55 is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2ACdc55 activity...
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections
Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...
Alpha-1-acid glycoprotein as a potential biomarker of breast cancer in at risk individuals
Thesis
Dewar, E. L. Alpha-1-acid glycoprotein as a potential biomarker of breast cancer in at risk individuals. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/9835
The identification of a blood-based diagnostic biomarker for breast cancer (BC) would be particularly beneficial to those at increased risk of developing BC and could result i...
Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae
Journal Article
Martínez-Pastor, M., De Llanos, R., Romero, A., & Puig, S. (2013)
Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae. International Journal of Molecular Sciences, 14(8), 15785-15809. https://doi.org/10.3390/ijms140815785
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in a wide variety of biological processes. Recent studies in Saccha...
Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability
Journal Article
Puig, S., Sanvisens, N., & Llanos, R. D. (2013)
Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability. Biomedical Journal, 36(2), https://doi.org/10.4103/2319-4170.110398
All eukaryotic organisms require an adequate, balanced concentration of deoxyribonucleoside triphosphates (dNTPs) in order to assure accurate DNA replication and repair, and t...
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila
Journal Article
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012)
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLOS ONE, 7(7), https://doi.org/10.1371/journal.pone.0040569
Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the d...
Phosphorylation of the epidermal growth factor
receptor (EGFR) is essential for interleukin-8
release from intestinal epithelial cells in response to
challenge with Escherichia coli O157 :H7 flagellin.
Journal Article
Fraser-Pitt, D. J., Cameron, P., McNeilly, T. N., Boyd, A., Manson, E. D. T., & Smith, D. G. E. (2011)
challenge with Escherichia coli O157 :H7 flagellin. Microbiology, 157, 2339-2347. https://doi.org/10.1099/mic.0.047670-0
Enterohaemorrhagic E. coli O157:H7 is a major food-borne and environmental pathogen responsible for both sporadic cases and outbreaks of food poisoning which can lead to serio...
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway
Journal Article
Hupp, T., Lin, Y., Henderson, P., Pettersson, S., Satsangi, J., Hupp, T. R., & Stevens, C. (2010)
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS Journal, 278(2), 354-370. https://doi.org/10.1111/j.1742-4658.2010.07959.x
We previously identified a novel interaction between tuberous sclerosis-2 (TSC2) and death-associated protein kinase-1 (DAPK), the consequence being that DAPK catalyses the in...
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Journal Article
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism, 11(1), 35-46. https://doi.org/10.1016/j.cmet.2009.11.010
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms includi...
Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling
Journal Article
Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. J., & Hupp, T. R. (2009)
Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284, 334-344. https://doi.org/10.1074/jbc.M805165200
Death-associated protein kinase (DAPK) is a multidomain enzyme that plays a central role in autophagic and apoptotic signaling, although the protein-protein interactions regul...