10 results

The lived experience of interferon-free treatments for hepatitis C: A thematic analysis

Journal Article
Whiteley, D., Whittaker, A., Elliott, L., & Cunningham-Burley, S. (2016)
The lived experience of interferon-free treatments for hepatitis C: A thematic analysis. International Journal of Drug Policy, 38, 21-28. https://doi.org/10.1016/j.drugpo.2016.10.013
Background: International discourse concerning the evolution in hepatitis C virus (HCV) therapy has tended to focus on improving outcomes, shortened treatment length and reduc...

Health-Related Quality of Life for individuals with hepatitis C: A narrative review

Journal Article
Whiteley, D., Elliott, L., Cunningham-Burley, S., & Whittaker, A. (2015)
Health-Related Quality of Life for individuals with hepatitis C: A narrative review. International Journal of Drug Policy, 26(10), 936-949. https://doi.org/10.1016/j.drugpo.2015.04.019
BACKGROUND The assessment of Health-Related Quality of Life (HRQoL) in hepatitis C (HCV) infected individuals continues to gain importance. However, rarely do reviews of this...

Emotion recognition by children with Down syndrome: investigation of specific impairments and error patterns.

Journal Article
Williams, K. R., NaWishart, J. G., Pitcairn, T. K. & Willis, D. (2005)
Emotion recognition by children with Down syndrome: investigation of specific impairments and error patterns. American journal of mental retardation : AJMR. 110, 387-392. ISSN 0895-8017
The ability of children with Down syndrome to recognize expressions of emotion was compared to performance in typically developing and nonspecific intellectual disability grou...

Hippocalcin functions as a calcium sensor in hippocampal LTD

Journal Article
Palmer, C., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., …Henley, J. M. (2005)
Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47(4), 487-494. https://doi.org/10.1016/j.neuron.2005.06.014
It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin sub...

Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents.

Journal Article
Dias, N., Goossens, J., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., …Bailly, C. (2005)
Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16(4), 949-958. https://doi.org/10.1021/bc050065x
We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derive...

Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model

Journal Article
Van Valckenborgh, E., Mincher, D., Di Salvo, A., Van Riet, I., Young, L., Van Camp, B., & Vanderkerken, K. (2005)
Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia, 19(9), 1628-1633. https://doi.org/10.1038/sj.leu.2403866
Multiple myeloma (MM) is an incurable B-cell cancer characterised by the monoclonal proliferation of tumour cells in the bone marrow (BM). It has been described that matrix me...

The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Journal Article
Palmer, C., Cotton, L., & Henley, J. M. (2005)
The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Pharmacological Reviews, 57, 253-277. https://doi.org/10.1124/pr.57.2.7
-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental importance in the brain. They are responsible for the majority of fast excitatory synapti...

Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure

Journal Article
Ramage, L., & Guy, K. (2004)
Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure. Inhalation Toxicology, 16(6-7), 447-452. https://doi.org/10.1080/08958370490439614
Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this s...

Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation.

Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P. F., Clouter, A., Guy, K., Brown, D. M., …Stone, V. (2001)
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation. Toxicology and Applied Pharmacology. 176, 10-17. doi:10.1006/taap.2001.9268. ISSN 0041-008X
In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. ...

Counselling for post-traumatic stress disorder

Book
Stradling, S. G., & Scott, M. J. (1999)
Counselling for post-traumatic stress disorder. Sage