Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment
Presentation / Conference
Male Reproductive Health and Advanced Bio-Nanomaterials: A focus on developing predictive assessment methods
Presentation / Conference
Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment
Presentation / Conference
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk
assessment. The altered physico-chemical properties of ENM mean traditi...
Nanoparticles and Neutrophil Activation
Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February)
Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland
Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are t...
Nanotoxicity.
Book Chapter
Hutchison, G. R., & Malone, E. M. (2011)
Nanotoxicity. In B. Booß-Bavnbek, B. Klösgen, J. Larsen, F. Pociot, & E. Renström (Eds.), Systems Biology of Regulated Exocytosis in Pancreatic β-Cells, 419-434. Springer. https://doi.org/10.1007/978-1-4419-6956-9_18
Nanotechnology, including the field of nanomedicine, promises to revolutionise/improve the way in which we live our lives. This atomic, molecular and macromolecular technology...
Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model.
Presentation / Conference
Fulton, N., Malone, E., O’Neil, M., & Hutchison, G. (2010, June)
Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model. Poster presented at Nanotoxicology 2010, Edinburgh
Nanoparticles (NP) are sized between 1 and 100 nanometers and are currently the subject of significant research due to their important role in the biomedical, materials and co...