The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability
Journal Article
Samvelyan, H. J., Huesa, C., Cui, L., Farquharson, C., & Staines, K. A. (2022)
The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability. Bone & Joint Research, 11(3), 162-170. https://doi.org/10.1302/2046-3758.113.bjr-2021-0259.r1
Aims
Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here,...
Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro
Journal Article
Staines, K. A., Myers, K., Little, K., Ralston, S. H., & Farquharson, C. (2021)
Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro. Calcified Tissue International, 109, 696-705. https://doi.org/10.1007/s00223-021-00882-9
Proton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear, but it has been...
Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis
Journal Article
Mellis, D., Staines, K. A., Peluso, S., Georgiou, I. C., Dora, N., Kubiak, M., …Ditzel, M. (2021)
Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. PLoS Genetics, 17(4), https://doi.org/10.1371/journal.pgen.1009275
Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian hom...
Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study
Journal Article
Staines, K. A., Hardy, R., Samvelyan, H. J., Ward, K. A., & Cooper, R. (2021)
Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study. Osteoarthritis and Cartilage, 29(3), 335-340. https://doi.org/10.1016/j.joca.2020.12.012
Objective
To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in the MRC National Survey of Health and Development (NSHD)...
Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway
Journal Article
Chen, Z., Gordillo-Martinez, F., Jiang, L., He, P., Hong, W., Wei, X., …Zhu, D. (2021)
Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovascular Research, 117(3), 820-835. https://doi.org/10.1093/cvr/cvaa090
Aims
Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic ...
Models of osteoarthritis: relevance and new insights
Journal Article
Samvelyan, H., Hughes, D., Stevens, C., & Staines, K. A. (2021)
Models of osteoarthritis: relevance and new insights. Calcified Tissue International, 109(3), 243-256. https://doi.org/10.1007/s00223-020-00670-x
Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most commo...
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity
Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020)
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40(1), https://doi.org/10.1042/BSR20190329
E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modeling/remodeling, throug...
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease
Journal Article
Morgan, S., Hooper, K. M., Milne, E. M., Farquharson, C., Stevens, C., & Staines, K. A. (2019)
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease. International Journal of Molecular Sciences, 20(23), https://doi.org/10.3390/ijms20236085
Patients with inflammatory bowel disease (IBD) often present poor bone health and are 40% more at risk of bone fracture. Studies have implicated autophagy in IBD pathology and...
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography
Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., …Lee, P. (2020)
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and len...
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential
Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5, https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...